N-(3-乙基-2-吡啶基)氨基甲酸叔丁酯合成路线 （共 6 条）
反应条件
1: 2-(tert-butoxycarbonylamino)-3-methylpyridine With n-butyllithium in tetrahydrofuran T=-40 - 0°C; 1 h; 2: methyl iodide in tetrahydrofuran T=-78 - -60°C; 0.5 h;
参考文献
TAIHO PHARMACEUTICAL CO., LTD.
Patent: US2012/108589 A1, 2012 ;
Location in patent: Page/Page column 28 ;
参考文献
Medivir AB
Patent: US5593993 A1, 1997 ;
反应条件
1: 84 percent / ethyl acetate; hexane / 0.83 h / 58 °C 2: 1.) n-BuLi / 1.) THF, 0 - 3 deg C, 1 h, 2.) THF, -75 deg C, 1 h View Scheme
参考文献
Synthesis, , # 7 p. 877 - 882
反应条件
1: 84 percent / ethyl acetate; hexane / 0.83 h / 58 °C 2: 1.) n-BuLi / 1.) THF, 0 - 3 deg C, 1 h, 2.) THF, -75 deg C, 1 h View Scheme
参考文献
Synthesis, , # 7 p. 877 - 882
反应条件
in hydrogenchloride; acetic acid
参考文献
Medivir AB
Patent: US5593993 A1, 1997 ;
反应条件
1: 1.) n-BuLi / 1.) THF, hexane, 0 - 3 deg C, 1 h, 2.) THF, hexane, from 6 deg C to 18 deg C, 1 h 2: 5.5 M HCl / 0.67 h / 50 °C View Scheme
参考文献
Hands, David; Bishop, Brian; Cameron, Mark; Edwards, John S.; Cottrell, Ian F.; Wright, Stanley H. B.
Synthesis, 1996 , # 7 p. 877 - 882
