2,3-二氢-1,4-苯并硫氮杂卓-5(4H)-酮合成路线 （共 9 条）
反应条件
sodium hydride in tetrahydrofuran; N,N-dimethyl-formamide; mineral oil T=0 - 20°C;
参考文献
F. HOFFMANN-LA ROCHE AG; LIANG, Chungen; WANG, Lisha; YUN, Hongying Yun; ZHENG, Xiufang
Patent: WO2013/53658 A1, 2013 ;
Location in patent: Page/Page column 15-16 ;
反应条件
sodium n-propanolate in propan-1-ol Heating;
参考文献
Ishibashi, Hiroyuki; Uegaki, Masayuki; Sakai, Manami; Takeda, Yoshifumi
Tetrahedron, 2001 , vol. 57, # 11 p. 2115 - 2120
参考文献
Ohmoto, Kazuyuki; Itagaki, Iori
Patent: US2003/162964 A1, 2003 ;
反应条件
1: sulfuric acid / methanol / 18 h / 0 °C / |Inert atmosphere; |Reflux 2: sodium hydride / tetrahydrofuran; N,N-dimethyl-formamide; mineral oil / 0 - 20 °C View Scheme
参考文献
F. HOFFMANN-LA ROCHE AG; LIANG, Chungen; WANG, Lisha; YUN, Hongying Yun; ZHENG, Xiufang
Patent: WO2013/53658 A1, 2013 ;
反应条件
tris-(2-chloro-ethyl)-amine; sulfuric acid in benzene
参考文献
Grunewald, Gary L.; Dahanukar, Vilas H.; Ching, Piao; Criscione, Kevin R.
Journal of Medicinal Chemistry, 1996 , vol. 39, # 18 p. 3539 - 3546
反应条件
sodium ethanolate in ethanol
参考文献
Wuensch,K.-H. et al.
Zeitschrift fuer Chemie (Stuttgart, Germany), 1967 , vol. 7, p. 185 - 186
反应条件
sodium methylate in methanol
参考文献
Jakob,F.; Schlack,P.
Chemische Berichte, 1963 , vol. 96, p. 88 - 92
反应条件
hydrogenchloride in tetrahydrofuran; methanol
参考文献
Ohmoto, Kazuyuki; Itagaki, Iori
Patent: US2003/162964 A1, 2003 ;
反应条件
lithium aluminium tetrahydride
参考文献
Hoffmann-La Roche Inc; Liang, Chungen; Wang, Lisha; Yun, Hongying; Zheng, Xiufang
Patent: US2013/90328 A1, 2013 ;
Location in patent: Paragraph 0106; 0107 ;
