1-(4-三氟甲基-苄基)-哌啶-4-胺合成路线 (共 2 条)
反应条件
bis-[(trifluoroacetoxy)iodo]benzene in water; acetonitrile T=65°C; Hoffmann rearrangement;
参考文献
Aventis Pharmaceuticals Inc.
Patent: EP1056744 B1, 2003 ;
Location in patent: Page/Page column 40 ;
反应条件
1: Cs2CO3; KI / various solvent(s) / 5 h / 100 °C 2: PhI(CF3CO2)2 / acetonitrile; H2O / 65 °C View Scheme
参考文献
Shum; Peet; Weintraub; Le; Zhao; Barbone; Cashman; Tsay; Dwyer; Loos; Powers; Kropp; Wright; Bitonti; Dumont; Borcherding
Nucleosides, Nucleotides and Nucleic Acids, 2001 , vol. 20, # 4-7 p. 1067 - 1078