1: 92 percent / diethyl ether / 5 h / 0 °C 2: 82 percent / POCl3 / pyridine / 8 h / Ambient temperature 3: 92 percent / BF3*Et2O / CH2Cl2 / 1 h / Ambient temperature 4: 81 percent / iPr2NEt / CH2Cl2 / 7 h / Ambient temperature 5: 59 percent / Na2CO3, MeI / H2O; acetonitrile / 3 h / Heating 6: 1.) HMPA, 15percent w/w n-BuLi / 1.) THF, hexane, -78 deg C, 15 min; 2.) THF, -78 deg C, 10 min; 0 deg C, 30 min; rt, 6 h 7: 2.) ethanethiol, BF3*Et2O / 1.) Methylene Blue / 1.) toluene, 220 deg C, 100 h; 2.) CH2Cl2, rt, 1 h 8: 52 percent / CrO3 / pyridine / 10 h / Ambient temperature View Scheme

1: 2.) ethanethiol, BF3*Et2O / 1.) Methylene Blue / 1.) toluene, 220 deg C, 100 h; 2.) CH2Cl2, rt, 1 h 2: 52 percent / CrO3 / pyridine / 10 h / Ambient temperature View Scheme

1: conc. HCl / methanol 2: 52 percent / CrO3, pyridine View Scheme

TAMPS in acetonitrile 4 h; RefluxInert atmosphere; stereoselective reaction;

lithium bromide in N,N-dimethyl-formamide T=125°C; 2 h; Inert atmosphere; Overall yield = 91 percent; Overall yield = 1.1 g;

1: 71.3 percent / pyridine / 20 h / 20 °C 2: 18 percent / 72 h / Heating View Scheme

TAMPS in acetonitrile 11 h; RefluxInert atmosphere; stereoselective reaction;

in methanol 72 h; Heating;

1: Jone's reagent / acetone / 20 °C 2: acetic acid; zinc / 0.25 h / Reflux View Scheme

acetic acid; zinc