4-氰基吡啶 N-氧化物合成路线 （共 31 条）
反应条件
N,N-dimethylcarbamoyl chloride in acetonitrile T=120°C; 8 h;
参考文献
Huo, Zhibao; Kosugi, Teruo; Yamamoto, Yoshinori
Tetrahedron Letters, 2008 , vol. 49, # 28 p. 4369 - 4371
反应条件
triethylamine in acetonitrile Heating;
参考文献
Sakamoto, Takao; Kaneda, Soh-ichi; Nishimura, Sumiko; Yamanaka, Hiroshi
Chemical and Pharmaceutical Bulletin, 1985 , vol. 33, # 2 p. 565 - 571
反应条件
1: 92 percent / 3 h / 90 - 100 °C 2: 75 percent / ethanol; H2O / 3 h / -18 - -12 °C View Scheme
参考文献
Greci, Lucedio; Alberti, Angelo; Carelli, Italo; Trazza, Antonio; Casini, Antonio
Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), 1984 , p. 2013 - 2018
反应条件
Behandeln des Reaktionsprodukts mit KCN in H2O;
参考文献
Feely; Beavers
Journal of the American Chemical Society, 1959 , vol. 81, p. 4004,4005
反应条件
phosphorus pentachloride; trichlorophosphate T=120 - 130°C; Chlorination; 3 h;
参考文献
Leroy; Bigan; Blondeau
Synthetic Communications, 1997 , vol. 27, # 17 p. 2905 - 2916
反应条件
1.1: 69 percent / POCl3 / 24 h / 100 °C 2.1: DIBAL / toluene / -15 °C 2.2: 80 percent / aq. HCl View Scheme
参考文献
Frey, Lisa F; Marcantonio, Karen; Frantz, Doug E; Murry, Jerry A; Tillyer, Richard D; Grabowski, Edward J.J; Reider, Paul J
Tetrahedron Letters, 2001 , vol. 42, # 39 p. 6815 - 6818
反应条件
ammonium chloride; indium in ethanol; water Hydrolysis; deoxygenation; Heating;
参考文献
Jeevanandam, Arumugasamy; Cartwright, Charles; Ling, Yong-Chien
Synthetic Communications, 2000 , vol. 30, # 17 p. 3153 - 3160
反应条件
N-ethyl-N,N-diisopropylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate in dichloromethane T=25°C; 15 h;
参考文献
Londregan, Allyn T.; Jennings, Sandra; Wei, Liuqing
Organic Letters, 2010 , vol. 12, # 22 p. 5254 - 5257
反应条件
1: tri-tert-butyl phosphine; palladium diacetate; potassium carbonate / toluene / 24 h / 120 °C / Inert atmosphere 2: phosphorus trichoride / dichloromethane / 1 h / 60 °C / Inert atmosphere View Scheme
参考文献
Duric, Sasa; Tzschucke, C. Christoph
Organic Letters, 2011 , vol. 13, # 9 p. 2310 - 2313
反应条件
hydrogenchloride; sodium methylate; sodium in methanol; 1,1-dimethylpropan-1-ol; water; acetic acid
参考文献
Ciba-Geigy Corporation
Patent: US5502196 A1, 1996 ;
