5-氨基-5-脱氧葡萄糖酸delta-内酰胺合成路线 （共 17 条）
反应条件
hydrogenchloride; hydrogen; palladium dihydroxide; palladium on activated charcoal in methanol; ethanol
48 h;
参考文献
Overkleeft, Herman S.; Wiltenburg, Jim van; Pandit, Upendra K.
Tetrahedron, 1994 , vol. 50, # 14 p. 4215 - 4224
反应条件
1: With sodium hydroxide; iodine in water
1.16667 h;
2: With silver carbonate in water
0.5 h;
参考文献
ALLERGAN, INC.
Patent: WO2006/37069 A1, 2006 ;
Location in patent: Page/Page column 47-48 ;
反应条件
sodium hydroxide; iodine
T=23°C; pH 8.5;
参考文献
Kajimoto, Tetsuya; Liu, Kevin K.-C.; Pederson, Richard L.; Zhong, Ziyang; Ichikawa, Yoshitaka; Porco Jr., John A.; Wong, Chi-Huey
Journal of the American Chemical Society, 1991 , vol. 113, # 16 p. 6187 - 6196
反应条件
1: With palladium 10 on activated carbon; hydrogen in methanol; ethyl acetate
T=20°C; 48 h;
2: With water
参考文献
Ravinder, Mettu; Reddy, Thatikonda Narendar; Mahendar, Budde; Rao, Vaidya Jayathirtha
Arkivoc, 2012 , vol. 2012, # 9 p. 287 - 302
反应条件
hydrogen; palladium in ethanol
参考文献
Fleet, George W.J.; Carpenter, Neil M.; Petursson, Sigthor; Ramsden, Nigel G.
Tetrahedron Letters, 1990 , vol. 31, # 3 p. 409 - 412
反应条件
1: pyridine / CH2Cl2
2: 75 percent / sodium azide / dimethylformamide
3: aqueous trifluoroacetic acid
4: 74 percent / bromine / dioxane; H2O
5: 1) tin(II)-chloride, 2) potassium carbonate / 1) methanol
6: hydrogen / palladium black / ethanol
View Scheme
参考文献
Fleet, George W.J.; Carpenter, Neil M.; Petursson, Sigthor; Ramsden, Nigel G.
Tetrahedron Letters, 1990 , vol. 31, # 3 p. 409 - 412
反应条件
1: 74 percent / bromine / dioxane; H2O
2: 1) tin(II)-chloride, 2) potassium carbonate / 1) methanol
3: hydrogen / palladium black / ethanol
View Scheme
参考文献
Fleet, George W.J.; Carpenter, Neil M.; Petursson, Sigthor; Ramsden, Nigel G.
Tetrahedron Letters, 1990 , vol. 31, # 3 p. 409 - 412
反应条件
1: aqueous trifluoroacetic acid
2: 74 percent / bromine / dioxane; H2O
3: 1) tin(II)-chloride, 2) potassium carbonate / 1) methanol
4: hydrogen / palladium black / ethanol
View Scheme
参考文献
Fleet, George W.J.; Carpenter, Neil M.; Petursson, Sigthor; Ramsden, Nigel G.
Tetrahedron Letters, 1990 , vol. 31, # 3 p. 409 - 412
反应条件
1: 75 percent / sodium azide / dimethylformamide
2: aqueous trifluoroacetic acid
3: 74 percent / bromine / dioxane; H2O
4: 1) tin(II)-chloride, 2) potassium carbonate / 1) methanol
5: hydrogen / palladium black / ethanol
View Scheme
参考文献
Fleet, George W.J.; Carpenter, Neil M.; Petursson, Sigthor; Ramsden, Nigel G.
Tetrahedron Letters, 1990 , vol. 31, # 3 p. 409 - 412
反应条件
1: H2O, Dowex 1x2 / 0.5 h / Ambient temperature; pH 8-10
2: I2, KI, aq. NaOH / 24 h / Ambient temperature
View Scheme
参考文献
Papandreou; Tong; Ganem
Journal of the American Chemical Society, 1993 , vol. 115, # 25 p. 11682 - 11690
