R-(+)-2-甲基-1-苯基-1-丙醇合成路线 （共 41 条）
反应条件
(R)-5-CF3-2-Ph-2,3-dihydroimidazo[1,2-a]pyridine; N-ethyl-N,N-diisopropylamine in chloroform
T=0°C; 30 h; Title compound not separated from byproducts;
参考文献
Birman, Vladimir B.; Uffman, Eric W.; Jiang, Hui; Li, Ximin; Kilbane, Corey J.
Journal of the American Chemical Society, 2004 , vol. 126, # 39 p. 12226 - 12227
反应条件
Birman's catalyst; trimethylacetic anhydride; N-ethyl-N,N-diisopropylamine in dichloromethane
T=20°C; 12 h; optical yield given as percent eeenantioselective reaction;
参考文献
Shiina, Isamu; Nakata, Kenya; Sugimoto, Masuhiro; Onda, Yu-Suke; Iizumi, Takashi; Ono, Keisuke
Heterocycles, 2009 , vol. 77, # 2 p. 801 - 810
反应条件
(1S,2R)-(+)-erythro-2-amino-1,2-diphenylethanol; benzoic acid in water; acetonitrile
T=20°C;
参考文献
Kodama, Koichi; Kobayashi, Yuka; Saigo, Kazuhiko
Chemistry - A European Journal, 2007 , vol. 13, # 7 p. 2144 - 2152
反应条件
(Rp)-xylyl-PHANEPHOS in chloroform-d1
T=-67 - 25°C; Title compound not separated from byproducts.;
参考文献
Driver, Tom G.; Harris, Jason R.; Woerpel
Journal of the American Chemical Society, 2007 , vol. 129, # 13 p. 3836 - 3837
反应条件
N-ethyl-N,N-diisopropylamine; CF3-PIP in chloroform
T=0°C; 30 - 30.25 h; Resolution of racemate; Product distribution / selectivity;
参考文献
Birman, Vladimir
Patent: US2005/256150 A1, 2005 ;
Location in patent: Page/Page column 15; 16; 18 ;
反应条件
1: isopropyl alcohol With [Ru(1,5-cyclooctadiene)Cl2]x; (8R,9R)-9-amino-(9-deoxy)epiquinine
T=20°C; 0.5 h; Inert atmosphere;
2: With potassium hydroxide
0.5 h; Inert atmosphere;
3: 1-phenyl-2-methyl-1-propanone T=0°C; 96 h; Inert atmosphere; enantioselective reaction;
参考文献
Jiang, Heyan
Journal of Chemical Research, 2013 , vol. 37, # 12 p. 761 - 763
反应条件
1: PhZnBr With trimethylaluminum; (1R,2S)-(+)-dibutylnorephedrine in tetrahydrofuran; toluene
T=20°C; 0.333333 h; Inert atmosphere;
2: isobutyraldehyde in tetrahydrofuran; toluene
T=20°C; 17 h; Inert atmosphere; optical yield given as percent eeenantioselective reaction;
参考文献
Glynn, Daniel; Shannon, Jonathan; Woodward, Simon
Chemistry - A European Journal, 2010 , vol. 16, # 3 p. 1053 - 1060
反应条件
1: isopropylmagnesium chloride With sodium methylate; zinc(II) chloride in diethyl ether
T=0 - 20°C; Inert atmosphere;
2: benzaldehyde With (S)-N-(3-methyl-1-(1-pyrrolidin-1-yl)butan-2-yl) diphenylphosphinic amideamine in diethyl ether
T=20°C; Inert atmosphere; optical yield given as percent ee;
参考文献
Hatano, Manabu; Mizuno, Tomokazu; Ishihara, Kazuaki
Chemical Communications, 2010 , vol. 46, # 30 p. 5443 - 5445
反应条件
n-butyllithium; (2S,2'S)-2-hydroxymethyl-1-lt;(1-methylpyrrolidine-2-yl)methylgt;pyrrolidine in toluene
T=-110°C; 1 h; Yield given. Yields of byproduct given;
参考文献
Mukaiyama, Teruaki
Tetrahedron, 1981 , vol. 37, # 23 p. 4111 - 4119
反应条件
diethylzinc; planar-chiral ferrocenyl oxazoline 3 in toluene
T=10°C; Title compound not separated from byproducts;
参考文献
Bolm, Carsten; Hermanns, Nina; Hildebrand, Jens P.; Muniz, Kilian
Angewandte Chemie (International Edition in English), 2000 , vol. 39, # 19 p. X3465-3467
