3-氨基-3-苯基丙酸甲酯合成路线 （共 24 条）
反应条件
2: 75 percent / NaHCO3 / CH2Cl2; H2O 3: 1.)KHMDS; 2.) MoOPH / 1.) toluene, THF, -78 deg C to -25 deg C; 2.) toluene, THF, -60 deg C, 3 h View Scheme
参考文献
Hanessian; Sanceau
Canadian Journal of Chemistry, 1996 , vol. 74, # 4 p. 621 - 624
反应条件
sodium tetrahydroborate; sulfuric acid in tetrahydrofuran T=20°C;
参考文献
Kellogg, Richard M.; Nieuwenhuijzen, Jose W.; Pouwer; Vries, Ton R.; Broxterman, Quirinus B.; Grimbergen, Reinier F.P.; Kaptein, Bernard; La Crois, Rene M.; De Wever, Ellen; Zwaagstra, Karen; Van Der Laan, Alexander C.
Synthesis, 2003 , # 10 p. 1626 - 1638
反应条件
tri-isobutyl aluminium in toluene 1.) 7 deg C, 24 h, 2.) 25 deg C, 7.5 h;
参考文献
Vorbruggen; Woodward
Tetrahedron, 1993 , vol. 49, # 8 p. 1625 - 1634
反应条件
potassium dihydrogenphosphate; water; Amano Lipase PS T=30°C; pH=8.2; 15.5 h; Resolution of racemate; Product distribution / selectivity;
参考文献
Ube Industries, Ltd.
Patent: EP1621529 A1, 2006 ;
Location in patent: Page/Page column 25-26 ;
反应条件
Methylobacterium sp. Y1-6 T=30°C; 24 h; Overall yield = 47 percentChromat.;
参考文献
Li, Yi; Wang, Wenfu; Huang, Yumian; Zou, Qianwen; Zheng, Guojun
Process Biochemistry, 2013 , vol. 48, # 11 p. 1674 - 1678
反应条件
potassium dihydrogenphosphate; water; Amano Lipase PS T=30°C; pH=8.2; 15.5 h; Resolution of racemate; Product distribution / selectivity;
参考文献
Ube Industries, Ltd.
Patent: EP1621529 A1, 2006 ;
Location in patent: Page/Page column 25-26 ;
反应条件
Methylobacterium sp. Y1-6 T=30°C; 24 h; Overall yield = 47 percentChromat.;
参考文献
Li, Yi; Wang, Wenfu; Huang, Yumian; Zou, Qianwen; Zheng, Guojun
Process Biochemistry, 2013 , vol. 48, # 11 p. 1674 - 1678
反应条件
potassium dihydrogenphosphate; water; Amano Lipase PS T=30°C; pH=8.2; 15.5 h; Resolution of racemate; Product distribution / selectivity;
参考文献
Ube Industries, Ltd.
Patent: EP1621529 A1, 2006 ;
Location in patent: Page/Page column 25-26 ;
反应条件
Methylobacterium sp. Y1-6 T=30°C; 24 h; Overall yield = 47 percentChromat.;
参考文献
Li, Yi; Wang, Wenfu; Huang, Yumian; Zou, Qianwen; Zheng, Guojun
Process Biochemistry, 2013 , vol. 48, # 11 p. 1674 - 1678
反应条件
sodium tetrahydroborate; sulfuric acid in tetrahydrofuran T=20°C;
参考文献
Kellogg, Richard M.; Nieuwenhuijzen, Jose W.; Pouwer; Vries, Ton R.; Broxterman, Quirinus B.; Grimbergen, Reinier F.P.; Kaptein, Bernard; La Crois, Rene M.; De Wever, Ellen; Zwaagstra, Karen; Van Der Laan, Alexander C.
Synthesis, 2003 , # 10 p. 1626 - 1638
