3-氨基-3-苯基丙酸甲酯合成路线 （共 24 条）
反应条件
potassium dihydrogenphosphate; water; Amano Lipase PS T=30°C; pH=8.2; 15.5 h; Resolution of racemate; Product distribution / selectivity;
参考文献
Ube Industries, Ltd.
Patent: EP1621529 A1, 2006 ;
Location in patent: Page/Page column 25-26 ;
反应条件
Carica papaya lipase in hexane T=45°C; Resolution of racemateEnzymatic reaction;
参考文献
You, Pengyong; Qiu, Jian; Su, Erzheng; Wei, Dongzhi
European Journal of Organic Chemistry, 2013 , # 3 p. 557 - 565
反应条件
Pseudomonas cepacia lipase immobilized on diatomite; water in 1,4-dioxane T=45°C; 102.5 h; Enzymatic reaction; optical yield given as percent eestereoselective reaction;
参考文献
Rodriguez-Mata, Maria; Garcia-Urdiales, Eduardo; Gotor-Fernandez, Vicente; Gotor, Vicente
Advanced Synthesis and Catalysis, 2010 , vol. 352, # 2-3 p. 395 - 406
反应条件
Candida antarctica Lipase type B in tert-butyl methyl ether T=45°C; 27 h; Inert atmosphereEnzymatic reaction; optical yield given as percent eestereoselective reaction;
参考文献
Rodriguez-Mata, Maria; Garcia-Urdiales, Eduardo; Gotor-Fernandez, Vicente; Gotor, Vicente
Advanced Synthesis and Catalysis, 2010 , vol. 352, # 2-3 p. 395 - 406
参考文献
Haycock-Lewandowski, Sarah J.; Wilder, Alexander; Ahman, Jens
Organic Process Research and Development, 2008 , vol. 12, # 6 p. 1094 - 1103
反应条件
1: methanol / 40 °C / |Inert atmosphere; |Reflux; |Large scale 2: sodium carbonate / dichloromethane; water / 0 - 10 °C / |Inert atmosphere; |Large scale 3: sodium hydroxide / methanol; isopropyl alcohol / 2 h / 20 °C / |Inert atmosphere; |Large scale View Scheme
参考文献
Haycock-Lewandowski, Sarah J.; Wilder, Alexander; Ahman, Jens
Organic Process Research and Development, 2008 , vol. 12, # 6 p. 1094 - 1103
反应条件
amidosulfamic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene T=160°C; 0.25 h;
参考文献
Campbell, Andrew D.; Birch, Alan M.
Synlett, 2005 , # 5 art. no. D32104ST, p. 834 - 838
反应条件
amidosulfamic acid T=160°C; 0.333333 h;
参考文献
Synlett, , # 5 art. no. D32104ST, p. 834 - 838
反应条件
1: methanol / 40 °C / |Inert atmosphere; |Reflux; |Large scale 2: sodium carbonate / dichloromethane; water / 0 - 10 °C / |Inert atmosphere; |Large scale 3: sodium hydroxide / methanol; isopropyl alcohol / 2 h / 20 °C / |Inert atmosphere; |Large scale 4: boron trifluoride / tetrahydrofuran / 3 h / 0 - 10 °C / |Inert atmosphere; |Large scale View Scheme
参考文献
Haycock-Lewandowski, Sarah J.; Wilder, Alexander; Ahman, Jens
Organic Process Research and Development, 2008 , vol. 12, # 6 p. 1094 - 1103
反应条件
2: 98 percent / 1) 40percent aq. NaOH, 2) conc HCl / 16 h / Ambient temperature View Scheme
参考文献
Wasserman, Harry H.; Berger, Gregory D.
Tetrahedron, 1983 , vol. 39, # 15 p. 2459 - 2464
