7-O-(三乙基硅烷基)紫杉醇合成路线 （共 56 条）
反应条件
pyridine hydrogenfluoride in tetrahydrofuran Ambient temperature;
参考文献
Dziedzic, Pawel; Schyman, Patrie; Kullberg, Martin; Cordova, Armando
Chemistry - A European Journal, 2009 , vol. 15, # 16 p. 4044 - 4048
反应条件
hydrogen; palladium dihydroxide in ethanol
Ambient temperature;
参考文献
Dziedzic, Pawel; Schyman, Patrie; Kullberg, Martin; Cordova, Armando
Chemistry - A European Journal, 2009 , vol. 15, # 16 p. 4044 - 4048
反应条件
hydrogen; palladium on activated charcoal in ethyl acetate
4 h;
参考文献
Chen, Shu-Hui; Huang, Stella; Wei, Jianmei; Farina, Vittorio
Tetrahedron, 1993 , vol. 49, # 14 p. 2805 - 2828
反应条件
1.1: 94 percent / imidazole / dimethylformamide / 1.5 h / 0 °C
2.1: t-BuLi / diethyl ether; pentane / 0.33 h / -78 °C
2.2: CuCN / diethyl ether; pentane / 0.5 h / 0 °C
2.3: 92 percent / diethyl ether; pentane / 1.33 h / -23 °C
3.1: 97 percent / HCl; H2O / tetrahydrofuran / 0.83 h / 0 °C
4.1: 92 percent / NMO; TPAP; molecular sieves 4 Angstroem / CH2Cl2 / 0.5 h / 0 °C
5.1: 90 percent / MeONa / methanol / 1 h / 0 °C
6.1: 94 percent / AlH3 / toluene; tetrahydrofuran / 2 h / -78 °C
7.1: 100 percent / CSA / CH2Cl2 / 1 h / 20 °C
8.1: 97 percent / DDQ; H2O / CH2Cl2 / 1 h / 20 °C
9.1: 90 percent / PDC / CH2Cl2 / 16 h / 20 °C
10.1: s-BuLi / cyclohexane / 0.42 h / -23 °C
10.2: 96 percent / cyclohexane; benzene / 1 h / 0 °C
11.1: 100 percent / TBAF / tetrahydrofuran / 1 h / 50 °C
12.1: 99 percent / imidazole / dimethylformamide / 0.25 h / 20 °C
13.1: 96 percent / tetrahydrofuran; hexamethylphosphoric acid triamide; diethyl ether / 0.5 h / -78 °C
14.1: 80 percent / NMO; TPAP; molecular sieves 4 Angstroem / CH2Cl2; acetonitrile / 1 h / 20 °C
15.1: 98 percent / PdCl2; H2O / dimethylformamide / 3.5 h / 20 °C
16.1: 71 percent / TiCl2; LiAlH4 / tetrahydrofuran / 0.33 h / 40 °C
17.1: Na; NH3 / tetrahydrofuran / 2 h / -78 - -45 °C
18.1: TBAF / tetrahydrofuran / 0.08 h / 20 °C
19.1: 100 percent / pyridine / CH2Cl2 / 1.17 h / -45 °C
20.1: 84 percent / DMAP / benzene / 10 h / 35 °C
21.1: HCl; H2O / tetrahydrofuran / 10 h / 60 °C
22.1: pyridine / 0.67 h / 20 °C
23.1: 76 percent / NMO; TPAP; molecular sieves 4 Angstroem / CH2Cl2 / 1 h / 20 °C
24.1: DMAP / 4 h / 100 °C
24.2: DMAP / toluene / 4 h / 100 °C
25.1: P(OMe)3 / 5 h / 110 °C
26.1: 78 percent / PCC; Celite; NaOAc / benzene / 11 h / 95 °C
27.1: 87 percent / K-Selectride / tetrahydrofuran / 4 h / -23 °C
28.1: 98 percent / pyridine / 0.17 h / -23 °C
29.1: 15 percent / CuBr; PhCO3(t-Bu) / acetonitrile / 13 h / -23 °C
30.1: 92 percent / OsO4; pyridine / diethyl ether / 17 h / 20 °C
31.1: 42 percent / DBU / toluene / 1.75 h / 50 °C
32.1: 91 percent / DMAP; pyridine / 13 h / 20 °C
33.1: 94 percent / tetrahydrofuran; cyclohexane; diethyl ether / 0.25 h / -78 °C
34.1: 96 percent / HF*pyridine / tetrahydrofuran / 1 h / 20 °C
35.1: 87 percent / pyridine / 0.5 h / 20 °C
36.1: 66 percent / DPTC; DMAP / toluene / 4 h / 73 °C
37.1: 76 percent / H2 / Pd(OH)2/C / ethanol / 23 h / 20 °C
View Scheme
参考文献
Mukaiyama, Teruaki; Shiina, Isamu; Iwadare, Hayato; Saitoh, Masahiro; Nishimura, Toshihiro; Ohkawa, Naoto; Sakoh, Hiroki; Nishimura, Koji; Tani, Yu-Ichirou; Hasegawa, Masatoshi; Yamada, Koji; Saitoh, Katsuyuki
Chemistry - A European Journal, 1999 , vol. 5, # 1 p. 121 - 161
反应条件
1.1: LiAlH4 / tetrahydrofuran / 0.67 h / 0 °C
2.1: 94 percent / imidazole / dimethylformamide / 1.5 h / 0 °C
3.1: t-BuLi / diethyl ether; pentane / 0.33 h / -78 °C
3.2: CuCN / diethyl ether; pentane / 0.5 h / 0 °C
3.3: 92 percent / diethyl ether; pentane / 1.33 h / -23 °C
4.1: 97 percent / HCl; H2O / tetrahydrofuran / 0.83 h / 0 °C
5.1: 92 percent / NMO; TPAP; molecular sieves 4 Angstroem / CH2Cl2 / 0.5 h / 0 °C
6.1: 90 percent / MeONa / methanol / 1 h / 0 °C
7.1: 94 percent / AlH3 / toluene; tetrahydrofuran / 2 h / -78 °C
8.1: 100 percent / CSA / CH2Cl2 / 1 h / 20 °C
9.1: 97 percent / DDQ; H2O / CH2Cl2 / 1 h / 20 °C
10.1: 90 percent / PDC / CH2Cl2 / 16 h / 20 °C
11.1: s-BuLi / cyclohexane / 0.42 h / -23 °C
11.2: 96 percent / cyclohexane; benzene / 1 h / 0 °C
12.1: 100 percent / TBAF / tetrahydrofuran / 1 h / 50 °C
13.1: 99 percent / imidazole / dimethylformamide / 0.25 h / 20 °C
14.1: 96 percent / tetrahydrofuran; hexamethylphosphoric acid triamide; diethyl ether / 0.5 h / -78 °C
15.1: 80 percent / NMO; TPAP; molecular sieves 4 Angstroem / CH2Cl2; acetonitrile / 1 h / 20 °C
16.1: 98 percent / PdCl2; H2O / dimethylformamide / 3.5 h / 20 °C
17.1: 71 percent / TiCl2; LiAlH4 / tetrahydrofuran / 0.33 h / 40 °C
18.1: Na; NH3 / tetrahydrofuran / 2 h / -78 - -45 °C
19.1: TBAF / tetrahydrofuran / 0.08 h / 20 °C
20.1: 100 percent / pyridine / CH2Cl2 / 1.17 h / -45 °C
21.1: 84 percent / DMAP / benzene / 10 h / 35 °C
22.1: HCl; H2O / tetrahydrofuran / 10 h / 60 °C
23.1: pyridine / 0.67 h / 20 °C
24.1: 76 percent / NMO; TPAP; molecular sieves 4 Angstroem / CH2Cl2 / 1 h / 20 °C
25.1: DMAP / 4 h / 100 °C
25.2: DMAP / toluene / 4 h / 100 °C
26.1: P(OMe)3 / 5 h / 110 °C
27.1: 78 percent / PCC; Celite; NaOAc / benzene / 11 h / 95 °C
28.1: 87 percent / K-Selectride / tetrahydrofuran / 4 h / -23 °C
29.1: 98 percent / pyridine / 0.17 h / -23 °C
30.1: 15 percent / CuBr; PhCO3(t-Bu) / acetonitrile / 13 h / -23 °C
31.1: 92 percent / OsO4; pyridine / diethyl ether / 17 h / 20 °C
32.1: 42 percent / DBU / toluene / 1.75 h / 50 °C
33.1: 91 percent / DMAP; pyridine / 13 h / 20 °C
34.1: 94 percent / tetrahydrofuran; cyclohexane; diethyl ether / 0.25 h / -78 °C
35.1: 96 percent / HF*pyridine / tetrahydrofuran / 1 h / 20 °C
36.1: 87 percent / pyridine / 0.5 h / 20 °C
37.1: 66 percent / DPTC; DMAP / toluene / 4 h / 73 °C
38.1: 76 percent / H2 / Pd(OH)2/C / ethanol / 23 h / 20 °C
View Scheme
参考文献
Mukaiyama, Teruaki; Shiina, Isamu; Iwadare, Hayato; Saitoh, Masahiro; Nishimura, Toshihiro; Ohkawa, Naoto; Sakoh, Hiroki; Nishimura, Koji; Tani, Yu-Ichirou; Hasegawa, Masatoshi; Yamada, Koji; Saitoh, Katsuyuki
Chemistry - A European Journal, 1999 , vol. 5, # 1 p. 121 - 161
反应条件
1.1: t-BuLi / diethyl ether; pentane / 0.33 h / -78 °C
1.2: CuCN / diethyl ether; pentane / 0.5 h / 0 °C
1.3: 92 percent / diethyl ether; pentane / 1.33 h / -23 °C
2.1: 97 percent / HCl; H2O / tetrahydrofuran / 0.83 h / 0 °C
3.1: 92 percent / NMO; TPAP; molecular sieves 4 Angstroem / CH2Cl2 / 0.5 h / 0 °C
4.1: 90 percent / MeONa / methanol / 1 h / 0 °C
5.1: 94 percent / AlH3 / toluene; tetrahydrofuran / 2 h / -78 °C
6.1: 100 percent / CSA / CH2Cl2 / 1 h / 20 °C
7.1: 97 percent / DDQ; H2O / CH2Cl2 / 1 h / 20 °C
8.1: 90 percent / PDC / CH2Cl2 / 16 h / 20 °C
9.1: s-BuLi / cyclohexane / 0.42 h / -23 °C
9.2: 96 percent / cyclohexane; benzene / 1 h / 0 °C
10.1: 100 percent / TBAF / tetrahydrofuran / 1 h / 50 °C
11.1: 99 percent / imidazole / dimethylformamide / 0.25 h / 20 °C
12.1: 96 percent / tetrahydrofuran; hexamethylphosphoric acid triamide; diethyl ether / 0.5 h / -78 °C
13.1: 80 percent / NMO; TPAP; molecular sieves 4 Angstroem / CH2Cl2; acetonitrile / 1 h / 20 °C
14.1: 98 percent / PdCl2; H2O / dimethylformamide / 3.5 h / 20 °C
15.1: 71 percent / TiCl2; LiAlH4 / tetrahydrofuran / 0.33 h / 40 °C
16.1: Na; NH3 / tetrahydrofuran / 2 h / -78 - -45 °C
17.1: TBAF / tetrahydrofuran / 0.08 h / 20 °C
18.1: 100 percent / pyridine / CH2Cl2 / 1.17 h / -45 °C
19.1: 84 percent / DMAP / benzene / 10 h / 35 °C
20.1: HCl; H2O / tetrahydrofuran / 10 h / 60 °C
21.1: pyridine / 0.67 h / 20 °C
22.1: 76 percent / NMO; TPAP; molecular sieves 4 Angstroem / CH2Cl2 / 1 h / 20 °C
23.1: DMAP / 4 h / 100 °C
23.2: DMAP / toluene / 4 h / 100 °C
24.1: P(OMe)3 / 5 h / 110 °C
25.1: 78 percent / PCC; Celite; NaOAc / benzene / 11 h / 95 °C
26.1: 87 percent / K-Selectride / tetrahydrofuran / 4 h / -23 °C
27.1: 98 percent / pyridine / 0.17 h / -23 °C
28.1: 15 percent / CuBr; PhCO3(t-Bu) / acetonitrile / 13 h / -23 °C
29.1: 92 percent / OsO4; pyridine / diethyl ether / 17 h / 20 °C
30.1: 42 percent / DBU / toluene / 1.75 h / 50 °C
31.1: 91 percent / DMAP; pyridine / 13 h / 20 °C
32.1: 94 percent / tetrahydrofuran; cyclohexane; diethyl ether / 0.25 h / -78 °C
33.1: 96 percent / HF*pyridine / tetrahydrofuran / 1 h / 20 °C
34.1: 87 percent / pyridine / 0.5 h / 20 °C
35.1: 66 percent / DPTC; DMAP / toluene / 4 h / 73 °C
36.1: 76 percent / H2 / Pd(OH)2/C / ethanol / 23 h / 20 °C
View Scheme
参考文献
Mukaiyama, Teruaki; Shiina, Isamu; Iwadare, Hayato; Saitoh, Masahiro; Nishimura, Toshihiro; Ohkawa, Naoto; Sakoh, Hiroki; Nishimura, Koji; Tani, Yu-Ichirou; Hasegawa, Masatoshi; Yamada, Koji; Saitoh, Katsuyuki
Chemistry - A European Journal, 1999 , vol. 5, # 1 p. 121 - 161
反应条件
1.1: 99 percent / imidazole / dimethylformamide / 0.25 h / 20 °C
2.1: 96 percent / tetrahydrofuran; hexamethylphosphoric acid triamide; diethyl ether / 0.5 h / -78 °C
3.1: 80 percent / NMO; TPAP; molecular sieves 4 Angstroem / CH2Cl2; acetonitrile / 1 h / 20 °C
4.1: 98 percent / PdCl2; H2O / dimethylformamide / 3.5 h / 20 °C
5.1: 71 percent / TiCl2; LiAlH4 / tetrahydrofuran / 0.33 h / 40 °C
6.1: Na; NH3 / tetrahydrofuran / 2 h / -78 - -45 °C
7.1: TBAF / tetrahydrofuran / 0.08 h / 20 °C
8.1: 100 percent / pyridine / CH2Cl2 / 1.17 h / -45 °C
9.1: 84 percent / DMAP / benzene / 10 h / 35 °C
10.1: HCl; H2O / tetrahydrofuran / 10 h / 60 °C
11.1: pyridine / 0.67 h / 20 °C
12.1: 76 percent / NMO; TPAP; molecular sieves 4 Angstroem / CH2Cl2 / 1 h / 20 °C
13.1: DMAP / 4 h / 100 °C
13.2: DMAP / toluene / 4 h / 100 °C
14.1: P(OMe)3 / 5 h / 110 °C
15.1: 78 percent / PCC; Celite; NaOAc / benzene / 11 h / 95 °C
16.1: 87 percent / K-Selectride / tetrahydrofuran / 4 h / -23 °C
17.1: 98 percent / pyridine / 0.17 h / -23 °C
18.1: 15 percent / CuBr; PhCO3(t-Bu) / acetonitrile / 13 h / -23 °C
19.1: 92 percent / OsO4; pyridine / diethyl ether / 17 h / 20 °C
20.1: 42 percent / DBU / toluene / 1.75 h / 50 °C
21.1: 91 percent / DMAP; pyridine / 13 h / 20 °C
22.1: 94 percent / tetrahydrofuran; cyclohexane; diethyl ether / 0.25 h / -78 °C
23.1: 96 percent / HF*pyridine / tetrahydrofuran / 1 h / 20 °C
24.1: 87 percent / pyridine / 0.5 h / 20 °C
25.1: 66 percent / DPTC; DMAP / toluene / 4 h / 73 °C
26.1: 76 percent / H2 / Pd(OH)2/C / ethanol / 23 h / 20 °C
View Scheme
参考文献
Mukaiyama, Teruaki; Shiina, Isamu; Iwadare, Hayato; Saitoh, Masahiro; Nishimura, Toshihiro; Ohkawa, Naoto; Sakoh, Hiroki; Nishimura, Koji; Tani, Yu-Ichirou; Hasegawa, Masatoshi; Yamada, Koji; Saitoh, Katsuyuki
Chemistry - A European Journal, 1999 , vol. 5, # 1 p. 121 - 161
反应条件
1.1: 90 percent / PDC / CH2Cl2 / 16 h / 20 °C
2.1: s-BuLi / cyclohexane / 0.42 h / -23 °C
2.2: 96 percent / cyclohexane; benzene / 1 h / 0 °C
3.1: 100 percent / TBAF / tetrahydrofuran / 1 h / 50 °C
4.1: 99 percent / imidazole / dimethylformamide / 0.25 h / 20 °C
5.1: 96 percent / tetrahydrofuran; hexamethylphosphoric acid triamide; diethyl ether / 0.5 h / -78 °C
6.1: 80 percent / NMO; TPAP; molecular sieves 4 Angstroem / CH2Cl2; acetonitrile / 1 h / 20 °C
7.1: 98 percent / PdCl2; H2O / dimethylformamide / 3.5 h / 20 °C
8.1: 71 percent / TiCl2; LiAlH4 / tetrahydrofuran / 0.33 h / 40 °C
9.1: Na; NH3 / tetrahydrofuran / 2 h / -78 - -45 °C
10.1: TBAF / tetrahydrofuran / 0.08 h / 20 °C
11.1: 100 percent / pyridine / CH2Cl2 / 1.17 h / -45 °C
12.1: 84 percent / DMAP / benzene / 10 h / 35 °C
13.1: HCl; H2O / tetrahydrofuran / 10 h / 60 °C
14.1: pyridine / 0.67 h / 20 °C
15.1: 76 percent / NMO; TPAP; molecular sieves 4 Angstroem / CH2Cl2 / 1 h / 20 °C
16.1: DMAP / 4 h / 100 °C
16.2: DMAP / toluene / 4 h / 100 °C
17.1: P(OMe)3 / 5 h / 110 °C
18.1: 78 percent / PCC; Celite; NaOAc / benzene / 11 h / 95 °C
19.1: 87 percent / K-Selectride / tetrahydrofuran / 4 h / -23 °C
20.1: 98 percent / pyridine / 0.17 h / -23 °C
21.1: 15 percent / CuBr; PhCO3(t-Bu) / acetonitrile / 13 h / -23 °C
22.1: 92 percent / OsO4; pyridine / diethyl ether / 17 h / 20 °C
23.1: 42 percent / DBU / toluene / 1.75 h / 50 °C
24.1: 91 percent / DMAP; pyridine / 13 h / 20 °C
25.1: 94 percent / tetrahydrofuran; cyclohexane; diethyl ether / 0.25 h / -78 °C
26.1: 96 percent / HF*pyridine / tetrahydrofuran / 1 h / 20 °C
27.1: 87 percent / pyridine / 0.5 h / 20 °C
28.1: 66 percent / DPTC; DMAP / toluene / 4 h / 73 °C
29.1: 76 percent / H2 / Pd(OH)2/C / ethanol / 23 h / 20 °C
View Scheme
参考文献
Mukaiyama, Teruaki; Shiina, Isamu; Iwadare, Hayato; Saitoh, Masahiro; Nishimura, Toshihiro; Ohkawa, Naoto; Sakoh, Hiroki; Nishimura, Koji; Tani, Yu-Ichirou; Hasegawa, Masatoshi; Yamada, Koji; Saitoh, Katsuyuki
Chemistry - A European Journal, 1999 , vol. 5, # 1 p. 121 - 161
反应条件
1.1: s-BuLi / cyclohexane / 0.42 h / -23 °C
1.2: 96 percent / cyclohexane; benzene / 1 h / 0 °C
2.1: 100 percent / TBAF / tetrahydrofuran / 1 h / 50 °C
3.1: 99 percent / imidazole / dimethylformamide / 0.25 h / 20 °C
4.1: 96 percent / tetrahydrofuran; hexamethylphosphoric acid triamide; diethyl ether / 0.5 h / -78 °C
5.1: 80 percent / NMO; TPAP; molecular sieves 4 Angstroem / CH2Cl2; acetonitrile / 1 h / 20 °C
6.1: 98 percent / PdCl2; H2O / dimethylformamide / 3.5 h / 20 °C
7.1: 71 percent / TiCl2; LiAlH4 / tetrahydrofuran / 0.33 h / 40 °C
8.1: Na; NH3 / tetrahydrofuran / 2 h / -78 - -45 °C
9.1: TBAF / tetrahydrofuran / 0.08 h / 20 °C
10.1: 100 percent / pyridine / CH2Cl2 / 1.17 h / -45 °C
11.1: 84 percent / DMAP / benzene / 10 h / 35 °C
12.1: HCl; H2O / tetrahydrofuran / 10 h / 60 °C
13.1: pyridine / 0.67 h / 20 °C
14.1: 76 percent / NMO; TPAP; molecular sieves 4 Angstroem / CH2Cl2 / 1 h / 20 °C
15.1: DMAP / 4 h / 100 °C
15.2: DMAP / toluene / 4 h / 100 °C
16.1: P(OMe)3 / 5 h / 110 °C
17.1: 78 percent / PCC; Celite; NaOAc / benzene / 11 h / 95 °C
18.1: 87 percent / K-Selectride / tetrahydrofuran / 4 h / -23 °C
19.1: 98 percent / pyridine / 0.17 h / -23 °C
20.1: 15 percent / CuBr; PhCO3(t-Bu) / acetonitrile / 13 h / -23 °C
21.1: 92 percent / OsO4; pyridine / diethyl ether / 17 h / 20 °C
22.1: 42 percent / DBU / toluene / 1.75 h / 50 °C
23.1: 91 percent / DMAP; pyridine / 13 h / 20 °C
24.1: 94 percent / tetrahydrofuran; cyclohexane; diethyl ether / 0.25 h / -78 °C
25.1: 96 percent / HF*pyridine / tetrahydrofuran / 1 h / 20 °C
26.1: 87 percent / pyridine / 0.5 h / 20 °C
27.1: 66 percent / DPTC; DMAP / toluene / 4 h / 73 °C
28.1: 76 percent / H2 / Pd(OH)2/C / ethanol / 23 h / 20 °C
View Scheme
参考文献
Mukaiyama, Teruaki; Shiina, Isamu; Iwadare, Hayato; Saitoh, Masahiro; Nishimura, Toshihiro; Ohkawa, Naoto; Sakoh, Hiroki; Nishimura, Koji; Tani, Yu-Ichirou; Hasegawa, Masatoshi; Yamada, Koji; Saitoh, Katsuyuki
Chemistry - A European Journal, 1999 , vol. 5, # 1 p. 121 - 161
反应条件
1.1: 100 percent / CSA / CH2Cl2 / 1 h / 20 °C
2.1: 97 percent / DDQ; H2O / CH2Cl2 / 1 h / 20 °C
3.1: 90 percent / PDC / CH2Cl2 / 16 h / 20 °C
4.1: s-BuLi / cyclohexane / 0.42 h / -23 °C
4.2: 96 percent / cyclohexane; benzene / 1 h / 0 °C
5.1: 100 percent / TBAF / tetrahydrofuran / 1 h / 50 °C
6.1: 99 percent / imidazole / dimethylformamide / 0.25 h / 20 °C
7.1: 96 percent / tetrahydrofuran; hexamethylphosphoric acid triamide; diethyl ether / 0.5 h / -78 °C
8.1: 80 percent / NMO; TPAP; molecular sieves 4 Angstroem / CH2Cl2; acetonitrile / 1 h / 20 °C
9.1: 98 percent / PdCl2; H2O / dimethylformamide / 3.5 h / 20 °C
10.1: 71 percent / TiCl2; LiAlH4 / tetrahydrofuran / 0.33 h / 40 °C
11.1: Na; NH3 / tetrahydrofuran / 2 h / -78 - -45 °C
12.1: TBAF / tetrahydrofuran / 0.08 h / 20 °C
13.1: 100 percent / pyridine / CH2Cl2 / 1.17 h / -45 °C
14.1: 84 percent / DMAP / benzene / 10 h / 35 °C
15.1: HCl; H2O / tetrahydrofuran / 10 h / 60 °C
16.1: pyridine / 0.67 h / 20 °C
17.1: 76 percent / NMO; TPAP; molecular sieves 4 Angstroem / CH2Cl2 / 1 h / 20 °C
18.1: DMAP / 4 h / 100 °C
18.2: DMAP / toluene / 4 h / 100 °C
19.1: P(OMe)3 / 5 h / 110 °C
20.1: 78 percent / PCC; Celite; NaOAc / benzene / 11 h / 95 °C
21.1: 87 percent / K-Selectride / tetrahydrofuran / 4 h / -23 °C
22.1: 98 percent / pyridine / 0.17 h / -23 °C
23.1: 15 percent / CuBr; PhCO3(t-Bu) / acetonitrile / 13 h / -23 °C
24.1: 92 percent / OsO4; pyridine / diethyl ether / 17 h / 20 °C
25.1: 42 percent / DBU / toluene / 1.75 h / 50 °C
26.1: 91 percent / DMAP; pyridine / 13 h / 20 °C
27.1: 94 percent / tetrahydrofuran; cyclohexane; diethyl ether / 0.25 h / -78 °C
28.1: 96 percent / HF*pyridine / tetrahydrofuran / 1 h / 20 °C
29.1: 87 percent / pyridine / 0.5 h / 20 °C
30.1: 66 percent / DPTC; DMAP / toluene / 4 h / 73 °C
31.1: 76 percent / H2 / Pd(OH)2/C / ethanol / 23 h / 20 °C
View Scheme
参考文献
Mukaiyama, Teruaki; Shiina, Isamu; Iwadare, Hayato; Saitoh, Masahiro; Nishimura, Toshihiro; Ohkawa, Naoto; Sakoh, Hiroki; Nishimura, Koji; Tani, Yu-Ichirou; Hasegawa, Masatoshi; Yamada, Koji; Saitoh, Katsuyuki
Chemistry - A European Journal, 1999 , vol. 5, # 1 p. 121 - 161
