1,4-二噁螺[4.5]癸烷-8-羧酸乙酯合成路线 （共 24 条）
反应条件
sulfuric acid in ethanol
参考文献
Organic and Biomolecular Chemistry, , vol. 4, # 24 p. 4431 - 4436
反应条件
1: 1.) LDA / 1) THF, -20 deg C, 1 h, 2) THF, -20 deg C, 30 min, -20 deg C --> rt, 1 h
2: N-(2-naphthalenesulfonyl)-D-valine, BH3*THF / various solvent(s) / 3 h / -78 °C
3: n-Bu4NF / tetrahydrofuran / 1 h / Ambient temperature
4: 1.) Me3Al / 1) CH2Cl2, toluene, rt, 30 min; 2) CH2Cl2, toluene. 50-55 deg C, 2 d
5: BnNEt3Cl, (EtO)2P(O)Cl, aq. NaOH / CH2Cl2 / 2 h / Ambient temperature
View Scheme
参考文献
Wu, Guangzhong; Tormos, Wanda
Journal of Organic Chemistry, 1997 , vol. 62, # 18 p. 6412 - 6414
反应条件
triphenylmethyllithium
1) cooling (ice-bath), 45 min, THF, hexane; 2) THF, hexane, cooling (ice-bath), 90 min; Yield given. Multistep reaction;
参考文献
Pettit, George R.; Harvey, Thomas B.
Synthetic Communications, 1981 , vol. 11, # 3 p. 167 - 178
反应条件
diisobutylaluminium hydride in toluene
T=-70 - -65°C; 0.5 - 1 h;
参考文献
Gruenenthal GMBH
Patent: US2009/48323 A1, 2009 ;
Location in patent: Page/Page column 14; 16 ;
