1,4-二噁螺[4.5]癸烷-8-羧酸乙酯合成路线 （共 24 条）
反应条件
camphor-10-sulfonic acid in toluene 20 h; Heating;
参考文献
Gruenenthal GmbH
Patent: US2008/312231 A1, 2008 ;
Location in patent: Page/Page column 17 ;
US 20080312231 A1
反应条件
toluene-4-sulfonic acid in toluene 18 h; Reflux;
参考文献
Stella Pharma Corporation; Osaka Prefecture University Public Corporation; KIRIHATA,Mitsunori; HATTORI,Yoshihide; UEHARA,Kohki; TAKENAKA,Hiroshi
Patent: EP2602261 A1, 2013 ;
Location in patent: Paragraph 0090; 0091 ;
反应条件
toluene-4-sulfonic acid in (2S)-N-methyl-1-phenylpropan-2-amine hydrate; ethylene glycol; benzene
反应条件
1: H2 / rhodium on aluminum oxide / 120 h 2: chromic acid 3: 93 percent / p-toluene sulfonic acid View Scheme
参考文献
Synthetic Communications, , vol. 11, # 3 p. 167 - 178
反应条件
1: 70 percent / HCl 2: H2 / rhodium on aluminum oxide / 120 h 3: chromic acid 4: 93 percent / p-toluene sulfonic acid View Scheme
参考文献
Synthetic Communications, , vol. 11, # 3 p. 167 - 178
反应条件
1: 15 g / H2SO4 2: 11 g / p-toluene-sulphonic acid / benzene / Heating View Scheme
参考文献
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, , vol. <B> 20, # 4 p. 339 - 340
反应条件
1: 69 g / H2SO4 2: sodium / benzene / 14 h / Heating 3: H2SO4 , H3PO4 , H2O / 6 h 4: 15 g / H2SO4 5: 11 g / p-toluene-sulphonic acid / benzene / Heating View Scheme
参考文献
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, , vol. <B> 20, # 4 p. 339 - 340
反应条件
1: sodium / benzene / 14 h / Heating 2: H2SO4 , H3PO4 , H2O / 6 h 3: 15 g / H2SO4 4: 11 g / p-toluene-sulphonic acid / benzene / Heating View Scheme
参考文献
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, , vol. <B> 20, # 4 p. 339 - 340
反应条件
1: H2SO4 , H3PO4 , H2O / 6 h 2: 15 g / H2SO4 3: 11 g / p-toluene-sulphonic acid / benzene / Heating View Scheme
参考文献
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, , vol. <B> 20, # 4 p. 339 - 340
