1-Boc-1H-吡咯并[3,2-c]吡啶合成路线 （共 13 条）
反应条件
4-(N,N-dimethlyamino)pyridine in acetonitrile T=20°C; 18 h;
参考文献
Blake, James F.; Boyd, Steven Armen; De Meese, Jason; Fong, Kin Chiu; Gaudino, John J.; Kaplan, Tomas; Marlow, Allison L.; Seo, Jeongbeob; Thomas, Allen A.; Tian, Hongqi; Cohen, Frederick; Young, Wendy B.
Patent: US2007/238726 A1, 2007 ;
Location in patent: Page/Page column 114 ;
US 20070238726 A1
反应条件
copper(l) iodide in DMF (N,N-dimethyl-formamide) T=80°C; 6 h;
参考文献
Zhang, Han-Cheng; Maryanoff, Bruce E.; Ye, Hong
Patent: US2004/192718 A1, 2004 ;
Location in patent: Page 15-17 ;
US 20040192718 A1
反应条件
lithium chloride; bis-triphenylphosphine-palladium(II) chloride in toluene 15 h; Heating;
参考文献
Bioorganic and Medicinal Chemistry, , vol. 16, # 9 p. 5303 - 5321
反应条件
1: H2 / Pd/C / ethanol / 60 °C 2: DMAP / acetonitrile View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 15, # 4 p. 977 - 982
反应条件
1: Et3N, CuI / Pd(PPh3)2Cl2 / 20 °C 2: CuI / dimethylformamide / 8 h / 80 °C 3: 30 percent / CuI / dimethylformamide / 6 h / 80 °C View Scheme
参考文献
Tetrahedron Letters, , vol. 39, # 29 p. 5159 - 5162
反应条件
1: 81 percent / PCl3 / 3.5 h / T < 0 deg C 2: 63 percent / dimethylformamide / 1 h / 90 °C 3: 91 percent / H2 / 10percent Pd/C / ethanol / 14.7 - 22.07 Torr / 1) 1 h, 20 deg C, 2) 3 h, 60 deg C 4: 1) NaOH, Bu4N*HSO4 / 1) CH2Cl2, 2) 1 h View Scheme
参考文献
Tetrahedron, , vol. 49, # 14 p. 2885 - 2914
反应条件
copper(l) iodide in N,N-dimethyl-formamide T=80°C; 6 h;
参考文献
Tetrahedron Letters, , vol. 39, # 29 p. 5159 - 5162
反应条件
1: 63 percent / dimethylformamide / 1 h / 90 °C 2: 91 percent / H2 / 10percent Pd/C / ethanol / 14.7 - 22.07 Torr / 1) 1 h, 20 deg C, 2) 3 h, 60 deg C 3: 1) NaOH, Bu4N*HSO4 / 1) CH2Cl2, 2) 1 h View Scheme
参考文献
Tetrahedron, , vol. 49, # 14 p. 2885 - 2914
反应条件
1: 91 percent / H2 / 10percent Pd/C / ethanol / 14.7 - 22.07 Torr / 1) 1 h, 20 deg C, 2) 3 h, 60 deg C 2: 1) NaOH, Bu4N*HSO4 / 1) CH2Cl2, 2) 1 h View Scheme
参考文献
Tetrahedron, , vol. 49, # 14 p. 2885 - 2914
反应条件
1: 92 percent / H2 / Raney nickel / ethanol; H2O / 14.7 - 22.07 Torr / 1) 15 h, 20 deg C, 2) 3-5 h, 60 deg C 2: 1) NaOH, Bu4N*HSO4 / 1) CH2Cl2, 2) 1 h View Scheme
参考文献
Tetrahedron, , vol. 49, # 14 p. 2885 - 2914
