(S)-4-溴苯乙烯氧化物合成路线 (共 12 条)
反应条件
titanium(IV) isopropylate; C50H46N2O4; dihydrogen peroxide in dichloromethane; water
T=20°C; 9 h; optical yield given as percent eeenantioselective reaction;
参考文献
Xiong, Donglu; Wu, Mei; Wang, Shoufeng; Li, Fuwei; Xia, Chungu; Sun, Wei
Tetrahedron Asymmetry, 2010 , vol. 21, # 3 p. 374 - 378
反应条件
sodium hydroxide in diethyl ether; water
T=20°C; 5 h;
参考文献
MITSUBISHI PHARMA CORPORATION; SANOFI-AVENTIS
Patent: WO2006/28290 A1, 2006 ;
Location in patent: Page/Page column 66 ;
WO 2006/028290 A1
反应条件
air; 4-nitro-benzoic acid; Jacobsen's (S,S)-(salen)Co(III) catalyst in various solvent(s)
T=20°C; 48 h;
参考文献
Bartoli, Giuseppe; Bosco, Marcella; Carlone, Armando; Locatelli, Manuela; Melchiorre, Paolo; Sambri, Letizia
Organic Letters, 2004 , vol. 6, # 22 p. 3973 - 3975
反应条件
1: With orthoacetic acid trimethyl ester; chloro-trimethyl-silane in dichloromethane
T=0°C; 1.5 h;
2: With potassium carbonate in methanol
T=20°C; 3 h;
参考文献
GLAXO GROUP LIMITED
Patent: WO2006/87169 A1, 2006 ;
Location in patent: Page/Page column 41 ;
WO 2006/087169 A1
反应条件
iodosylbenzene; homochiral chloroiron(III) porphyrin in benzene
T=25°C; 3 h; other reagents, solvents, temperatures, reaction times; Product distribution;
参考文献
Gross, Zeev; Ini, Santiago
Journal of Organic Chemistry, 1997 , vol. 62, # 16 p. 5514 - 5521
反应条件
methyllithium in tetrahydrofuran
T=-100°C; 0.0166667 h;
参考文献
Midura, Wanda H.
Synlett, 2006 , # 5 p. 733 - 736
反应条件
Aspergillus niger CGMCC 0496 in phosphate buffer; N,N-dimethyl-formamide
T=25°C; pH=8.0; 0.666667 h;
参考文献
Jin, Hao; Li, Zu-Yi; Dong, Xiao-Wei
Organic and Biomolecular Chemistry, 2004 , vol. 2, # 3 p. 408 - 414
反应条件
water in ethanol
T=27°C; 2 h; biohydrolysis using Beauveria sulfurescens; pH 8; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Pedragosa-Moreau; Morisseau; Zylber; Archelas; Baratti; Furstoss
Journal of Organic Chemistry, 1996 , vol. 61, # 21 p. 7402 - 7407
反应条件
sodium hydroxide in tetrahydrofuran
T=25°C; Title compound not separated from byproducts;
参考文献
Cordes, David B.; Kwong, Tracey J.; Morgan, Kellie A.; Singaram, Bakthan
Tetrahedron Letters, 2006 , vol. 47, # 3 p. 349 - 351
反应条件
1: pyridine
2: NaOH / methanol / 2 h / 20 °C
View Scheme
参考文献
Barlow, Thomas; Dipple, Anthony
Chemical Research in Toxicology, 1998 , vol. 11, # 1 p. 44 - 53