6-氯-吡嗪羰酰氯(9ci)合成路线 （共 7 条）
反应条件
thionyl chloride in benzene 1.5 h; Heating;
参考文献
Dlabal, Karel; Dolezal, Martin; Machacek, Milos
Collection of Czechoslovak Chemical Communications, 1993 , vol. 58, # 2 p. 452 - 454
反应条件
1: 3-chloro-benzenecarboperoxoic acid / 1,2-dichloro-ethane / 16 h / 60 °C 2: thionyl chloride / 8 h / Reflux 3: ethanol; sodium hydroxide / 2 h / 20 °C 4: oxalyl dichloride / dichloromethane; N,N-dimethyl-formamide / 3 h / 20 °C View Scheme
参考文献
Scanio, Marc J. C.; Shi, Lei; Bunnelle, William H.; Anderson, David J.; Helfrich, Rosalind J.; Malysz, John; Thorin-Hagene, Kirsten K.; Van Handel, Ceclia E.; Marsh, Kennan C.; Lee, Chih-Hung; Gopalakrishnan, Murali
Journal of Medicinal Chemistry, 2011 , vol. 54, # 21 p. 7678 - 7692
反应条件
1: ethanol; sodium hydroxide / 2 h / 20 °C 2: oxalyl dichloride / dichloromethane; N,N-dimethyl-formamide / 3 h / 20 °C View Scheme
参考文献
Scanio, Marc J. C.; Shi, Lei; Bunnelle, William H.; Anderson, David J.; Helfrich, Rosalind J.; Malysz, John; Thorin-Hagene, Kirsten K.; Van Handel, Ceclia E.; Marsh, Kennan C.; Lee, Chih-Hung; Gopalakrishnan, Murali
Journal of Medicinal Chemistry, 2011 , vol. 54, # 21 p. 7678 - 7692
反应条件
1: thionyl chloride / 8 h / Reflux 2: ethanol; sodium hydroxide / 2 h / 20 °C 3: oxalyl dichloride / dichloromethane; N,N-dimethyl-formamide / 3 h / 20 °C View Scheme
参考文献
Scanio, Marc J. C.; Shi, Lei; Bunnelle, William H.; Anderson, David J.; Helfrich, Rosalind J.; Malysz, John; Thorin-Hagene, Kirsten K.; Van Handel, Ceclia E.; Marsh, Kennan C.; Lee, Chih-Hung; Gopalakrishnan, Murali
Journal of Medicinal Chemistry, 2011 , vol. 54, # 21 p. 7678 - 7692
反应条件
ammonium hydroxide in dichloromethane T=20°C; 2 h;
参考文献
Servusova, Barbora; Paterova, Pavla; Mandikova, Jana; Kubicek, Vladimir; Kucera, Radim; Kunes, Jiri; Dolezal, Martin; Zitko, Jan
Bioorganic and Medicinal Chemistry Letters, 2014 , vol. 24, # 2 p. 450 - 453
反应条件
triethylamine in dichloromethane 2 h; Inert atmosphere;
参考文献
Nikishkin, Nicolai I.; Huskens, Jurriaan; Verboom, Willem
Tetrahedron Letters, 2013 , vol. 54, # 14 p. 1857 - 1861
反应条件
thionyl chloride in toluene 1 h; Reflux;
参考文献
Servusova, Barbora; Eibinova, Drahomira; Dolezal, Martin; Kubicek, Vladimir; Paterova, Pavla; Pesko, Matus; Kral'ova, Katarina
Molecules, 2012 , vol. 17, # 11 p. 13183 - 13198
