4-苯甲氧基苯(甲)酰氯合成路线 （共 47 条）
反应条件
2-(N,N-dimethylamino)-pyridine; sodium carbonate; triethylamine in dichloromethane; toluene
参考文献
Showa Shell Sekiyu K.K.
Patent: US5116531 A1, 1992 ;
反应条件
2-(N,N-dimethylamino)-pyridine; triethylamine in (2S)-N-methyl-1-phenylpropan-2-amine hydrate; dichloromethane
参考文献
Showa Shell Sekiyo Kabushiki Kaisha
Patent: US5130050 A1, 1992 ;
反应条件
in pyridine; water; toluene
参考文献
Chisso Corporation
Patent: EP216530 B1, 1991 ;
反应条件
1: pyridine / 3 h / 20 °C 2: KOH / pyridine / 4 h / 60 °C 3: sulfuric acid / acetic acid / 1.5 h / 60 °C 4: BCl3 / CH2Cl2 / 1.5 h / -65 °C View Scheme
参考文献
British Journal of Pharmacology, , vol. 142, # 5 p. 811 - 820
反应条件
1: pyridine / 2 h / 70 - 80 °C 2: KOH / pyridine / 80 °C 3: 90 percent / conc. H2SO4, acetic acid / 1 h / 50 °C 4: 67 percent / dimethyldioxirane / acetone / 0 °C 5: 92 percent / K2CO3 / acetone / Heating 6: 93 percent / AlCl3 / acetonitrile / 0.5 h / Ambient temperature 7: 60 percent / K2CO3 / methanol / 1.5 h / Heating 8: 87 percent / H2 / 10percent Pd/C / methanol; ethyl acetate / Ambient temperature View Scheme
参考文献
Horie, Tokunaru; Shibata, Kenichi; Yamashita, Kazuyo; Kawamura, Yasuhiko; Tsukayama, Masao
Chemical and Pharmaceutical Bulletin, 1997 , vol. 45, # 3 p. 446 - 451
反应条件
tin(IV) chloride; benzene
参考文献
Royer; Demerseman
Bulletin de la Societe Chimique de France, 1959 , p. 1682,1685
反应条件
4-pyrrolidin-1-ylpyridine; triethylamine in dichloromethane 3 h; Heating; Yield given;
参考文献
Deschenaux, Robert; Marendaz, Jean-Luc; Santiago, Julio
Helvetica Chimica Acta, 1993 , vol. 76, # 2 p. 865 - 876
反应条件
1.1: 4-(N,N-dimethlyamino)pyridine; triethylamine / dichloromethane / 1 h / 20 °C / Cooling with ice; Inert atmosphere 2.1: potassium tert-butylate / tetrahydrofuran / 1 h / Reflux; Inert atmosphere 3.1: toluene-4-sulfonic acid / benzene / 7 h / Reflux; Inert atmosphere 4.1: boron trichloride / dichloromethane; toluene / 12 h / -78 - 20 °C / Inert atmosphere 4.2: 0.5 h / 20 °C View Scheme
参考文献
Oshitari, Tetsuta; Okuyama, Yuji; Miyata, Yoshiki; Kosano, Hiroshi; Takahashi, Hideyo; Natsugari, Hideaki
Bioorganic and Medicinal Chemistry, 2011 , vol. 19, # 23 p. 7085 - 7092
反应条件
triethylamine in dichloromethane T=25°C; 16 h;
参考文献
Cowart, Marlon D.; Bennani, Youssef L.; Faghih, Ramin; Black, Lawrence A.
Patent: US2002/183309 A1, 2002 ;
反应条件
triethylamine in dichloromethane
参考文献
Faghih, Ramin; Dwight, Wesley; Gentles, Robert; Phelan, Kathleen; Esbenshade, Timothy A; Ireland, Lynne; Miller, Thomas R; Kang, Chae-Hee; Fox, Gerard B; Gopalakrishnan, Sujatha M; Hancock, Arthur A; Bennani, Youssef L
Bioorganic and Medicinal Chemistry Letters, 2002 , vol. 12, # 15 p. 2031 - 2034
