4-溴-2-乙基-1-硝基苯合成路线 （共 10 条）
反应条件
1: With hydrogen bromide; sodium nitrite in water T=0 - 12°C; 0.5 h; 2: With CuSO4‵5H2O; hydrogen bromide; copper in water T=15 - 20°C; Sandmeyer Reaction;
参考文献
NIMBLEGEN SYSTEMS GMBH; STENGELE, Klaus-Peter
Patent: WO2012/136604 A1, 2012 ;
Location in patent: Page/Page column 51-52 ;
反应条件
dihydrogen peroxide; trifluoroacetic anhydride in dichloromethane T=0°C; Reflux;
参考文献
GALAPAGOS NV; MENET, Christel; SCHMITT, Benoît; GENEY, Raphaël; DOYLE, Kevin; PEACH, Joanne; PALMER, Nicholas; JONES, Graham; HARDY, David; DUFFY, James
Patent: WO2013/117649 A1, 2013 ;
Location in patent: Paragraph 0021 ;
反应条件
hydrogen bromide; sodium nitrite in water T=0 - 3°C; 0.0833333 h;
参考文献
Buehler, Sigrid; Lagoja, Irene; Giegrich, Heiner; Stengele, Klaus-Peter; Pfleiderer, Wolfgang
Helvetica Chimica Acta, 2004 , vol. 87, # 3 p. 620 - 659
反应条件
1.1: H2SO4; HNO3 / 1.25 h / -20 - -10 °C 1.2: 54 percent / NaOH; water 2.1: aq. HBr; NaNO2 / H2O / 0.08 h / 0 °C 2.2: urea / H2O / 0.17 h 2.3: 80 percent / CuSO4*5H2O; Cu; HBr / H2O / 1 h / 75 °C View Scheme
参考文献
NIMBLEGEN SYSTEMS GMBH; STENGELE, Klaus-Peter
Patent: WO2012/136604 A1, 2012 ;
反应条件
1.1: 20 °C 2.1: nitric acid; sulfuric acid / -30 - -10 °C 3.1: hydrogen bromide / water / 0.5 h / Reflux 4.1: sodium nitrite; hydrogen bromide / water / 0.5 h / 0 - 12 °C 4.2: 15 - 20 °C View Scheme
参考文献
NIMBLEGEN SYSTEMS GMBH; STENGELE, Klaus-Peter
Patent: WO2012/136604 A1, 2012 ;
反应条件
1.1: hydrogen bromide / water / 0.5 h / Reflux 2.1: sodium nitrite; hydrogen bromide / water / 0.5 h / 0 - 12 °C 2.2: 15 - 20 °C View Scheme
参考文献
NIMBLEGEN SYSTEMS GMBH; STENGELE, Klaus-Peter
Patent: WO2012/136604 A1, 2012 ;
反应条件
2,3-dicyano-5,6-dichloro-p-benzoquinone 1.) THF, -15 deg C, 2.) THF, RT, overnight; Yield given. Multistep reaction;
参考文献
Bentley, Stephen J.; Milner, David J.
Journal of Organometallic Chemistry, 1993 , vol. 447, # 1 p. 1 - 3
反应条件
sulfuric acid; sodium nitrite
参考文献
Uyeo
Nippon Kagaku Kaishi, 1942 , vol. 63, p. 1452,1455
Chem.Abstr., 1947 , p. 3066
反应条件
1: acetic acid; sulfuric acid; nitric acid 2: aq.-ethanolic hydrochloric acid 3: ethanolic sulfuric acid; aqueous sodium nitrite solution View Scheme
参考文献
Uyeo
Nippon Kagaku Kaishi, 1942 , vol. 63, p. 1452,1455
Chem.Abstr., 1947 , p. 3066
反应条件
1: aq.-ethanolic hydrochloric acid 2: ethanolic sulfuric acid; aqueous sodium nitrite solution View Scheme
参考文献
Uyeo
Nippon Kagaku Kaishi, 1942 , vol. 63, p. 1452,1455
Chem.Abstr., 1947 , p. 3066
