3,4-亚甲二氧-beta-硝基苯乙烯合成路线 （共 27 条）
反应条件
ammonium acetate; acetic acid T=22°C; 3 h; ultrasound;
参考文献
McNulty, James; Steere, Jennifer A.; Wolf, Sonja
Tetrahedron Letters, 1998 , vol. 39, # 44 p. 8013 - 8016
反应条件
hydrogenchloride; sodium hydroxide in methanol; nitromethane; water
参考文献
Abbott Laboratories
Patent: US5767144 A1, 1998 ;
US 5767144 A
反应条件
tert.-butylnitrite; 2,2,6,6-tetramethyl-1-piperidinyloxy, free radical in acetonitrile T=50°C; 6 h; stereoselective reaction;
参考文献
Manna, Srimanta; Jana, Sandipan; Saboo, Tapish; Maji, Arun; Maiti, Debabrata
Chemical Communications, 2013 , vol. 49, # 46 p. 5286 - 5288
反应条件
ammonium acetate; acetic acid in nitromethane
参考文献
Abbott Laboratories
Patent: US6162927 A1, 2000 ;
US 6162927 A
反应条件
potassium hydrogensulfate in toluene 1 h; Heating;
参考文献
Hirao, Haruna; Yamauchi, Satoshi; Ishibashi, Fumio
Bioscience, Biotechnology and Biochemistry, 2007 , vol. 71, # 3 p. 741 - 745
反应条件
CaO modified benzyl bromide T=102°C; Henry Nitro Aldol Condensation; 5 h;
参考文献
Research on Chemical Intermediates, , vol. 39, # 8 p. 3715 - 3725
反应条件
1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / |Reflux 2: ethanol / 14 h / |Reflux 3: pyridine / dichloromethane / 1.5 h / 0 - 20 °C 4: trichlorophosphate / acetonitrile / 1 h / |Reflux; |Inert atmosphere 5: [[(η6-p-cymene)((1S,2S)-N-p-toluenesulfonyl-1,2-diphenylethylenediamine)]Ru]; formic acid; triethylamine / N,N-dimethyl-formamide / 20 °C 6: water; sodium hydroxide / ethanol / 3 h / 20 °C 7: thionyl chloride / dichloromethane / 1.5 h / 0 - 20 °C 8: sodium hydrogencarbonate / dichloromethane / 1.5 h / 20 °C View Scheme
参考文献
Sun, Haifeng; Zhu, Liyuan; Yang, Huicui; Qian, Wangke; Guo, Lin; Zhou, Shengbin; Gao, Bo; Li, Zeng; Zhou, Yu; Jiang, Hualiang; Chen, Kaixian; Zhen, Xuechu; Liu, Hong
Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 4 p. 856 - 868
反应条件
zinc(II) tetrahydroborate in ethylene glycol dimethyl ether T=0 - 5°C; 6 h;
参考文献
Ranu; Chakraborty
Tetrahedron, 1992 , vol. 48, # 25 p. 5317 - 5322
反应条件
1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / |Reflux 2: ethanol / 14 h / |Reflux 3: pyridine / dichloromethane / 1.5 h / 0 - 20 °C 4: trichlorophosphate / acetonitrile / 1 h / |Reflux; |Inert atmosphere 5: [[(η6-p-cymene)((1S,2S)-N-p-toluenesulfonyl-1,2-diphenylethylenediamine)]Ru]; formic acid; triethylamine / N,N-dimethyl-formamide / 20 °C 6: water; sodium hydroxide / ethanol / 3 h / 20 °C 7: thionyl chloride / dichloromethane / 1.5 h / 0 - 20 °C 8: sodium hydrogencarbonate / dichloromethane / 1.5 h / 20 °C View Scheme
参考文献
Sun, Haifeng; Zhu, Liyuan; Yang, Huicui; Qian, Wangke; Guo, Lin; Zhou, Shengbin; Gao, Bo; Li, Zeng; Zhou, Yu; Jiang, Hualiang; Chen, Kaixian; Zhen, Xuechu; Liu, Hong
Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 4 p. 856 - 868
反应条件
titanium tetrachloride; tetraethylammonium p-toluenesulfonate in N,N-dimethyl-formamide electroreduction - 4 mA/cm2;
参考文献
Synthesis, , # 7 p. 631 - 633
