哌嗪,1-(2,3-二氢-1,4-苯并二噁烯-6-基)合成路线 （共 3 条）
反应条件
trifluoroacetic acid in dichloromethane T=0°C; 1 h;
参考文献
Hodgetts; Kieltyka; Brodbeck; Tran; Wasley; Thurkauf
Bioorganic and Medicinal Chemistry, 2001 , vol. 9, # 12 p. 3207 - 3213
反应条件
potassium carbonate in chlorobenzene
参考文献
Neurogen Corporation
Patent: US6177566 B1, 2001 ;
US 6177566 B1
反应条件
1: 57 percent / tri(o-tolyl)phosphine; tris(dibenzylideneacetone)dipalladium(0); sodium t-butoxide / toluene / 18 h / Heating 2: 75 percent / trifluoroacetic acid / CH2Cl2 / 1 h / 0 °C View Scheme
参考文献
Song, Jiho; Kim, Young Jin; Min, Kyung Hoon; Lee, Hyun-E; Kim, Su Yeon; Kim, Dong-Seok
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 22 p. 6943 - 6946,4
