(R)-十八烷酸-2,3-二羟丙酯合成路线 （共 9 条）
反应条件
amberlyst 15 in methanol; dichloromethane 2 h; Inert atmosphereReflux;
参考文献
Nakamura, Hiroyuki; Ueda, Noriko; Ban, Hyun Seung; Ueno, Manabu; Tachikawa, Shoji
Organic and Biomolecular Chemistry, 2012 , vol. 10, # 7 p. 1374 - 1380
反应条件
1: With dichloro-acetic acid; pyrrole in dichloromethane T=20°C; 0.25 h; 2: With iron(III) chloride in diethyl ether T=20°C; 0.5 h; Further stages.;
参考文献
Reese, Colin B.; Yan, Hongbin
Journal of the Chemical Society. Perkin Transactions 1, 2001 , # 15 p. 1807 - 1815
反应条件
1: EDC / tetrahydrofuran / 0 °C 2: Dowex 50 W / methanol / 20 °C View Scheme
参考文献
Woo, Song Lee; Mi, Jeong Kim; Beck, Young-Il; Park, Yong-Dae; Jeong, Tae-Sook
Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 15 p. 3573 - 3575
反应条件
1: Et3N; DMAP / CH2Cl2 / 0.83 h / 0 - 20 °C 2: CF3CO2H; CF3CH2OH; B(OEt)2 / 5 h / 20 °C View Scheme
参考文献
Gaffney, Piers R.J.; Reese, Colin B.
Tetrahedron Letters, 1997 , vol. 38, # 14 p. 2539 - 2542
反应条件
water; acetic acid T=50°C; 2 h;
参考文献
Chen, Chao-Yuan; Han, Wei-Bo; Chen, Hui-Jun; Wu, Yikang; Gao, Po
European Journal of Organic Chemistry, 2013 , # 20 p. 4311 - 4318
反应条件
water; acetic acid T=50°C; 12 h; Time;
参考文献
Chen, Chao-Yuan; Han, Wei-Bo; Chen, Hui-Jun; Wu, Yikang; Gao, Po
European Journal of Organic Chemistry, 2013 , # 20 p. 4311 - 4318
反应条件
1: 76 percent / glacial AcOH / 20 - 35 °C / 15 Torr 2: 1.794 g / 1-methylimidazole; 2,6-Cl2C6H3COCl / CH2Cl2 / 1.33 h / 20 °C 3: Cl2CHCO2H; pyrrole / CH2Cl2 / 0.08 h / 20 °C View Scheme
参考文献
Gaffney, Piers R.J.; Reese, Colin B.
Tetrahedron Letters, 1997 , vol. 38, # 14 p. 2539 - 2542
反应条件
1: toluene-4-sulfonic acid / 6 h / 20 °C
2: acetic acid; water / 2 h / 50 °C
View Scheme
参考文献
Chen, Chao-Yuan; Han, Wei-Bo; Chen, Hui-Jun; Wu, Yikang; Gao, Po
European Journal of Organic Chemistry, 2013 , # 20 p. 4311 - 4318
反应条件
1: toluene-4-sulfonic acid / 6 h / 20 °C
2: acetic acid; water / 12 h / 50 °C
View Scheme
参考文献
Chen, Chao-Yuan; Han, Wei-Bo; Chen, Hui-Jun; Wu, Yikang; Gao, Po
European Journal of Organic Chemistry, 2013 , # 20 p. 4311 - 4318
