4,4,5,5,5-五氟戊醇合成路线 （共 17 条）
反应条件
triethylamine in dichloromethane T=0 - 20°C; 3 - 12 h; Product distribution / selectivity;
参考文献
Chugai Seiyaku Kabushiki Kaisha
Patent: US6645951 B1, 2003 ;
Location in patent: Page/Page column 107; 142-143 ;
反应条件
sulfuric acid in pyridine; water; acetone
参考文献
Schering Aktiengesellschaft
Patent: US5502046 A1, 1996 ;
反应条件
di-isopropyl azodicarboxylate; triphenylphosphine in tetrahydrofuran 1.) 0 deg C, 30 min; 2.) 0 deg C, 30 min then 25 deg C, 1 h;
参考文献
Li, Xun; Provencher, Louis; Singh, Shankar M.
Tetrahedron Letters, 1994 , vol. 35, # 49 p. 9141 - 9144
反应条件
1: 33.9 g / triethylamine / CH2Cl2 / 0 - 20 °C 2: 51 percent / acetone / 12 h / 20 °C View Scheme
参考文献
BAYER INTELLECTUAL PROPERTY GMBH; Wintermantel, Tim; Möller, Carsten; Bothe, Ulrich; Nubbemeyer, Reinhard; Zorn, Ludwig; Kosemund, Dirk; Ter Laak, Antonius; Bohlmann, Rolf; Wortmann, Lars; Bierer, Donald
Patent: US2013/252890 A1, 2013 ;
反应条件
triphenylphosphine in tetrahydrofuran
参考文献
Schering Aktiengesellschaft
Patent: US5502046 A1, 1996 ;
反应条件
1: 88 percent / 1.) triphenylphosphine, diisopropyl azodicarboxylate / tetrahydrofuran / 1.) 0 deg C, 30 min; 2.) 0 deg C, 30 min then 25 deg C, 1 h 2: 65 percent / 2N aq. sodium hydroxide / 3 h / 100 °C View Scheme
参考文献
Li, Xun; Provencher, Louis; Singh, Shankar M.
Tetrahedron Letters, 1994 , vol. 35, # 49 p. 9141 - 9144
反应条件
potassium permanganate in water T=65 - 70°C;
参考文献
Mahmood, Arshed; Robinson, Graham E.; Powell, Lyn
Organic Process Research and Development, 1999 , vol. 3, # 5 p. 363 - 364
