7alpha,12alpha-二羟基-3-氧代-5beta-胆烷-24-酸甲酯合成路线 （共 12 条）
反应条件
Ag2CO3 on Celite in toluene RefluxInert atmosphere;
参考文献
Li, Qingjiang; Tochtrop, Gregory P.
Tetrahedron Letters, 2011 , vol. 52, # 32 p. 4137 - 4139
反应条件
hydrogen; palladium on activated charcoal in ethyl acetate P=735.5 Torr; 4 h; Ambient temperature;
参考文献
Iqbal; Elliott
Steroids, 1989 , vol. 53, # 3-5 p. 413 - 425
反应条件
dimethoxydioxirane*H2O in acetone T=0 - 5°C; Oxidation; 16 h; 2 equiv. of reagent;
参考文献
Buxton, P. Christopher; Marples, Brian A.; Toon, Richard C.; Waddington, Victoria L.
Tetrahedron Letters, 1999 , vol. 40, # 25 p. 4729 - 4732
反应条件
1: sulfuric acid 2: aluminium tert-butylate; benzene View Scheme
参考文献
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM); GRENOT, Catherine; CUILLERON, Claude
Patent: WO2011/73419 A1, 2011 ;
反应条件
aluminium phenoxide; benzene
参考文献
Jones; Webb; Smith
Journal of the Chemical Society, 1949 , p. 2164,2167
Full Text Show Details
Kuwada; Morimoto
Bulletin of the Chemical Society of Japan, 1942 , vol. 17, p. 147,150
反应条件
methanesulfonic acid; sodium sulfate 0.0333333 h; Microwave irradiation;
参考文献
Cravotto, Giancarlo; Binello, Arianna; Boffa, Luisa; Rosati, Ornelio; Boccalini, Marco; Chimichi, Stefano
Steroids, 2006 , vol. 71, # 6 p. 469 - 475
参考文献
Jones; Webb; Smith
Journal of the Chemical Society, 1949 , p. 2164,2167
Full Text Show Details
Kuwada; Morimoto
Bulletin of the Chemical Society of Japan, 1942 , vol. 17, p. 147,150
参考文献
Jones; Webb; Smith
Journal of the Chemical Society, 1949 , p. 2164,2167
Full Text Show Details
Kuwada; Morimoto
Bulletin of the Chemical Society of Japan, 1942 , vol. 17, p. 147,150
反应条件
1.1: phosphorous pentoxide / chloroform / 4 h / 20 °C / Inert atmosphere 2.1: “IBX” / dimethyl sulfoxide / 72 h / 40 °C / Inert atmosphere 3.1: ammonia; lithium; tert-butyl alcohol / tetrahydrofuran / 0.08 h / -78 °C / Inert atmosphere 4.1: potassium tri-sec-butyl-borohydride / tetrahydrofuran / 2 h / -78 °C / Inert atmosphere 5.1: hydrogenchloride / methanol / 2 h / Reflux; Inert atmosphere 5.2: 8 h / Reflux; Inert atmosphere View Scheme
参考文献
Li, Qingjiang; Tochtrop, Gregory P.
Tetrahedron Letters, 2011 , vol. 52, # 32 p. 4137 - 4139
反应条件
1: 25 percent / DDQ / dioxane / 10 h / Heating 2: H2 / tris(triphenylphosphine)-rhodium chloride / benzene 3: 23 percent / NaBH4 / pyridine / 20 h / Ambient temperature View Scheme
参考文献
Iqbal; Elliott
Steroids, 1989 , vol. 53, # 3-5 p. 413 - 425
