3-酮基-7alpha,12alpha-二羟基-5alpha-胆酸甲酯合成路线 （共 18 条）
反应条件
1: methanol 2: m-iodoxybenzoic acid, diphenyl diselenide / toluene / 18 h / Heating 3: MeOH, Na2CO3 / 1 h / Ambient temperature 4: hydrogen, chlorotris(triphenylphosphine)rhodium / benzene; ethanol / 25 h View Scheme
参考文献
Zhu, Xingpei; Amouzou, Etchri; McLean, Stewart
Canadian Journal of Chemistry, 1987 , vol. 65, p. 2447 - 2449
反应条件
ammonia; lithium Yield given. Multistep reaction;
参考文献
Iida, Takashi; Momose, Toshiaki; Chang, Frederic C.; Nambara, Toshio
Chemical and Pharmaceutical Bulletin, 1986 , vol. 34, # 5 p. 1934 - 1938
反应条件
1: 82 percent / Br2-DMF 2: 1.) semicarbazide, NaOAc; 2.) pyruvic acid / 1.) water, AcOH, 60 deg C, 30 min, then room temp. 1 h; 2.) water, AcOH, room temp. 24 h 3: 97 percent 4: 1.) Li-NH3 View Scheme
参考文献
Iida, Takashi; Momose, Toshiaki; Chang, Frederic C.; Nambara, Toshio
Chemical and Pharmaceutical Bulletin, 1986 , vol. 34, # 5 p. 1934 - 1938
反应条件
1: 1.) semicarbazide, NaOAc; 2.) pyruvic acid / 1.) water, AcOH, 60 deg C, 30 min, then room temp. 1 h; 2.) water, AcOH, room temp. 24 h 2: 97 percent 3: 1.) Li-NH3 View Scheme
参考文献
Iida, Takashi; Momose, Toshiaki; Chang, Frederic C.; Nambara, Toshio
Chemical and Pharmaceutical Bulletin, 1986 , vol. 34, # 5 p. 1934 - 1938
反应条件
1: 97 percent 2: 1.) Li-NH3 View Scheme
参考文献
Iida, Takashi; Momose, Toshiaki; Chang, Frederic C.; Nambara, Toshio
Chemical and Pharmaceutical Bulletin, 1986 , vol. 34, # 5 p. 1934 - 1938
反应条件
hydrogen cation Yield given;
参考文献
Iida; Nishida; Chang; Niwa; Goto; Nambara
Chemical and Pharmaceutical Bulletin, 1993 , vol. 41, # 4 p. 763 - 765
反应条件
1: 88 percent / K-Selectride / tetrahydrofuran / 3 h / -20 °C 2: 100 percent / methanolic KOH View Scheme
参考文献
Iida; Nishida; Chang; Niwa; Goto; Nambara
Chemical and Pharmaceutical Bulletin, 1993 , vol. 41, # 4 p. 763 - 765
反应条件
1: 88 percent / K-Selectride / tetrahydrofuran / 3 h / -20 °C 2: 100 percent / methanolic KOH View Scheme
参考文献
Iida; Nishida; Chang; Niwa; Goto; Nambara
Chemical and Pharmaceutical Bulletin, 1993 , vol. 41, # 4 p. 763 - 765
