1-甲基-5-(三丁基锡基)咪唑合成路线 (共 3 条)
反应条件
1: 1-methyl-1H-imidazole With n-butyllithium; N,N,N',N,-tetramethylethylenediamine in tetrahydrofuran T=-20 - 20°C; 1.5 h; 2: tributyltin chloride in tetrahydrofuran T=-20 - 20°C; 17 h;
参考文献
CHUGAI SEIYAKU KABUSHIKI KAISHA; Sakai, Toshiyuki
Patent: EP1982982 A1, 2008 ;
Location in patent: Page/Page column 79-80 ;
反应条件
1: 1-methyl-1H-imidazole With n-butyllithium; N,N,N',N,-tetramethylethylenediamine in hexanes T=-20°C; 0.5 h; 2: tributyltin chloride in hexanes T=-20 - 20°C;
参考文献
WO2005/90333 A1, ;
Page/Page column 91 ;
反应条件
tetrakis(triphenylphosphine) palladium(0) in N,N-dimethyl-formamide T=95°C; Stille Cross Coupling; 40 h; Inert atmosphereLarge scale;
参考文献
Ragan; Raggon; Hill; Jones; McDermott; Munchhof; Marx; Casavant; Cooper; Doty; Lu
Organic Process Research and Development, 2003 , vol. 7, # 5 p. 676 - 683