2-氨基-5-苯基-噻吩-3-羧酸合成路线 （共 2 条）
反应条件
1: With sodium hydroxide; water in methanol 2 h; Heating / reflux; 2: With hydrogenchloride; water in methanol pH=3 - 5;
参考文献
ASTRAZENECA AB; ASTRAZENECA UK LIMITED
Patent: WO2005/66163 A2, 2005 ;
Location in patent: Page/Page column 55 ;
WO 2005/066163 A2
反应条件
thionyl chloride T=0°C; 24 h; Reflux;
参考文献
Hinsberger, Stefan; De Jong, Johannes C.; Groh, Matthias; Haupenthal, Joerg; Hartmann, Rolf W.
European Journal of Medicinal Chemistry, 2014 , vol. 76, p. 343 - 351
