反应条件
1.1: HCl / 16 h / 20 °C
2.1: NaH / dimethylformamide / 0.5 h / 20 °C
2.2: dimethylformamide / 1 h / 80 °C
3.1: 253 mg / lithium hydroxide monohydrate / tetrahydrofuran / 2 h / 60 °C
4.1: Et3N; bis(oxo-3-oxazolidinyl)phosphoryl chloride / CH2Cl2 / 0.5 h / 20 °C
4.2: 60 percent / CH2Cl2 / 16 h / 20 °C
View Scheme
参考文献
Nazare, Marc; Will, David W.; Matter, Hans; Schreuder, Herman; Ritter, Kurt; Urmann, Matthias; Essrich, Melanie; Bauer, Armin; Wagner, Michael; Czech, Joerg; Lorenz, Martin; Laux, Volker; Wehner, Volkmar
Journal of Medicinal Chemistry, 2005 , vol. 48, # 14 p. 4511 - 4525
