hydrogenchloride in water; ethyl acetate T=25 - 35°C;

1: With hydrogenchloride; water in methanol T=25°C; 2.16667 h; 2: With hydrogenchloride in dichloromethane T=0 - 25°C; pH=3; 0.916667 h;

1.1: NaBH4; Et2BOMe / -78 °C 2.1: aq. NaOH 2.2: (+)-α-methylbenzylamine View Scheme

Candida famata RIFY7455 in dimethyl sulfoxide T=30°C; pH=7; 20 h; Aerobic conditionspotassium phosphate buffer (pH 7.0); Product distribution / selectivity;

water; sodium hydroxide in methanol T=20°C; 2 h; Product distribution / selectivity;

1.1: DMSO; P2O5; Et3N 2.1: NaOH; (n-octyl)3MeNCl / toluene; H2O 3.1: DIBAH 4.1: NaH; n-BuLi 5.1: NaBH4; Et2BOMe / -78 °C 6.1: aq. NaOH 6.2: (+)-α-methylbenzylamine View Scheme

1.1: hydrogen / palladium 10 on activated carbon / ethyl acetate / 2 h / 20 °C / Inert atmosphere 2.1: piperidine / N,N-dimethyl-formamide / 10.25 h / 20 - 40 °C / Inert atmosphere 3.1: hydrogenchloride / water; methanol / 0 - 20 °C 4.1: sodium tetrahydroborate; diethyl methoxy borane / tetrahydrofuran; methanol / 0.5 h / -78 °C 4.2: 1 h / 50 °C 5.1: sodium hydroxide; water / methanol / 2 h / 20 °C View Scheme

1.1: toluene / 0.25 h / 25 °C 1.2: 14 h / 10 - 75 °C / Inert atmosphere 1.3: 0.75 h / 0 - 25 °C / pH 2.5 2.1: sulfuric acid / water; methanol / 22.25 h / 25 - 65 °C 2.2: 0.75 h / 0 - 25 °C / pH 6 3.1: toluene / 5 h / 25 °C / Inert atmosphere 3.2: 3 h 3.3: 2 h / 40 °C 4.1: potassium carbonate / dimethyl sulfoxide / 7 h / 75 °C 5.1: water; oxalic acid / methanol / 6 h / 35 °C 5.2: 2.75 h / 10 - 30 °C / pH 7 6.1: hydrogenchloride; water / methanol / 2.17 h / 25 °C 6.2: 0.92 h / 0 - 25 °C / pH 3 View Scheme

1.1: sulfuric acid / water; methanol / 22.25 h / 25 - 65 °C 1.2: 0.75 h / 0 - 25 °C / pH 6 2.1: toluene / 5 h / 25 °C / Inert atmosphere 2.2: 3 h 2.3: 2 h / 40 °C 3.1: potassium carbonate / dimethyl sulfoxide / 7 h / 75 °C 4.1: water; oxalic acid / methanol / 6 h / 35 °C 4.2: 2.75 h / 10 - 30 °C / pH 7 5.1: hydrogenchloride; water / methanol / 2.17 h / 25 °C 5.2: 0.92 h / 0 - 25 °C / pH 3 View Scheme

1.1: toluene / 5 h / 25 °C / Inert atmosphere 1.2: 3 h 1.3: 2 h / 40 °C 2.1: potassium carbonate / dimethyl sulfoxide / 7 h / 75 °C 3.1: water; oxalic acid / methanol / 6 h / 35 °C 3.2: 2.75 h / 10 - 30 °C / pH 7 4.1: hydrogenchloride; water / methanol / 2.17 h / 25 °C 4.2: 0.92 h / 0 - 25 °C / pH 3 View Scheme