(4R,6S)-6-[[(1E)-2-环丙基-4-(4-氟苯基)-3-喹啉基]乙烯基]-2,2-二甲基-1,3-二氧六环-4-乙酸叔丁酯合成路线 （共 27 条）
反应条件
1.1: toluene / 0.25 h / 25 °C 1.2: 14 h / 10 - 75 °C / Inert atmosphere 1.3: 0.75 h / 0 - 25 °C / pH 2.5 2.1: sulfuric acid / water; methanol / 22.25 h / 25 - 65 °C 2.2: 0.75 h / 0 - 25 °C / pH 6 3.1: toluene / 5 h / 25 °C / Inert atmosphere 3.2: 3 h 3.3: 2 h / 40 °C 4.1: potassium carbonate / dimethyl sulfoxide / 7 h / 75 °C View Scheme
反应条件
1.1: sulfuric acid / water; methanol / 22.25 h / 25 - 65 °C 1.2: 0.75 h / 0 - 25 °C / pH 6 2.1: toluene / 5 h / 25 °C / Inert atmosphere 2.2: 3 h 2.3: 2 h / 40 °C 3.1: potassium carbonate / dimethyl sulfoxide / 7 h / 75 °C View Scheme
反应条件
1.1: toluene / 5 h / 25 °C / Inert atmosphere 1.2: 3 h 1.3: 2 h / 40 °C 2.1: potassium carbonate / dimethyl sulfoxide / 7 h / 75 °C View Scheme
反应条件
2,2,6,6-tetramethylpiperidinyl-lithium in tetrahydrofuran 3 h; Ambient temperature; Yield given. Yields of byproduct given;
参考文献
Tetrahedron Letters, , vol. 34, # 3 p. 513 - 516
反应条件
2,2,6,6-tetramethylpiperidinyl-lithium 1.) THF, RT, 30 min, 2.) THF, 3 h; Yield given. Multistep reaction;
参考文献
Bulletin of the Chemical Society of Japan, , vol. 68, # 1 p. 364 - 372
反应条件
hydrogenchloride; water in acetonitrile 3 h; Large scale;
参考文献
US2013/72688 A1, ;
Paragraph 0060-0062 ;
反应条件
1.1: water; oxalic acid / methanol / 6 h / 35 °C 1.2: 2.75 h / 10 - 30 °C / pH 7 2.1: sodium hydroxide; water / methanol / 1.67 h / 0 °C 2.2: 0.67 h / 25 °C 3.1: hydrogenchloride / dichloromethane; water / 0.83 h / 0 - 25 °C / pH 3 View Scheme
参考文献
MSN Laboratories Limited
Patent: US2012/16129 A1, 2012 ;
