alpha-生育酚喹啉醇合成路线 （共 11 条）
反应条件
hydrogen; palladium on activated charcoal in ethyl acetate
参考文献
Cohen; Lopresti; Neukom
Journal of Organic Chemistry, 1981 , vol. 46, # 12 p. 2445 - 2450
反应条件
1: 89 percent / ferric chloride / diethyl ether; methanol; H2O / 0.5 h 2: 100 percent / H2 / 5percent Pd/C / ethyl acetate View Scheme
参考文献
Cohen; Lopresti; Neukom
Journal of Organic Chemistry, 1981 , vol. 46, # 12 p. 2445 - 2450
反应条件
1: pyridine / 0 °C 2: methanol / 50 °C 3: LiAlH4 / tetrahydrofuran / Heating 4: TsOH / Ambient temperature 5: SO2Cl2 / CH2Cl2 / -40 °C 6: Et3N / CH2Cl2 / -40 - 20 °C 7: Raney Ni W4 / ethanol / Heating 8: LiAlH4 / diethyl ether / Ambient temperature View Scheme
参考文献
Inoue, Seiichi; Ikeda, Hiroshi; Sato, Shuichi; Horie, Kiyohiro; Ota, Tomomi; et al.
Journal of Organic Chemistry, 1987 , vol. 52, # 24 p. 5495 - 5497
反应条件
1: TsOH / Ambient temperature 2: SO2Cl2 / CH2Cl2 / -40 °C 3: Et3N / CH2Cl2 / -40 - 20 °C 4: Raney Ni W4 / ethanol / Heating 5: LiAlH4 / diethyl ether / Ambient temperature View Scheme
参考文献
Inoue, Seiichi; Ikeda, Hiroshi; Sato, Shuichi; Horie, Kiyohiro; Ota, Tomomi; et al.
Journal of Organic Chemistry, 1987 , vol. 52, # 24 p. 5495 - 5497
反应条件
1: LiAlH4 / tetrahydrofuran / Heating 2: TsOH / Ambient temperature 3: SO2Cl2 / CH2Cl2 / -40 °C 4: Et3N / CH2Cl2 / -40 - 20 °C 5: Raney Ni W4 / ethanol / Heating 6: LiAlH4 / diethyl ether / Ambient temperature View Scheme
参考文献
Inoue, Seiichi; Ikeda, Hiroshi; Sato, Shuichi; Horie, Kiyohiro; Ota, Tomomi; et al.
Journal of Organic Chemistry, 1987 , vol. 52, # 24 p. 5495 - 5497
反应条件
1: 85 percent / Ti(OCHMe2)4 /Me3COOH / D-(-)-DMT / CH2Cl2 / -20 °C 2: pyridine / 0 °C 3: methanol / 50 °C 4: LiAlH4 / tetrahydrofuran / Heating 5: TsOH / Ambient temperature 6: SO2Cl2 / CH2Cl2 / -40 °C 7: Et3N / CH2Cl2 / -40 - 20 °C 8: Raney Ni W4 / ethanol / Heating 9: LiAlH4 / diethyl ether / Ambient temperature View Scheme
参考文献
Inoue, Seiichi; Ikeda, Hiroshi; Sato, Shuichi; Horie, Kiyohiro; Ota, Tomomi; et al.
Journal of Organic Chemistry, 1987 , vol. 52, # 24 p. 5495 - 5497
反应条件
1: potassium hydroxide / ethanol / 1 h / 10 °C 2: anhydrous iron chloride; water 3: Pearlman's catalist; hydrogen View Scheme
参考文献
Shrader, William D.; Amagata, Akiko; Barnes, Adam; Hinman, Andrew; Jankowski, Orion; Lee, Edgar; Kheifets, Viktoria; Komatsuzaki, Ryo; Mollard, Paul; Murase, Katsuyuki; Rioux, Patrice; Wesson, Kieron; Miller, Guy
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 1 p. 391 - 395
参考文献
John et al.
Hoppe-Seyler's Zeitschrift fuer Physiologische Chemie, 1939 , vol. 257, p. 173,175
参考文献
John et al.
Hoppe-Seyler's Zeitschrift fuer Physiologische Chemie, 1939 , vol. 257, p. 173,175
反应条件
toluene-4-sulfonic acid in benzene T=80°C; 1.25 h;
参考文献
Cohen; Lopresti; Neukom
Journal of Organic Chemistry, 1981 , vol. 46, # 12 p. 2445 - 2450
