1-[[2-(2,5-二氢-5-氧代-1,2,4-噁二唑-3-基)[1,1-联苯]-4-基]甲基]-2-乙氧基-1H-苯并咪唑-7-羧酸甲酯合成路线 (共 22 条)
反应条件
1: 55 percent / hydroxylamine / dimethylsulfoxide / 15 h / 75 °C 2: pyridine / dimethylformamide / 0.5 h / 0 °C 3: xylene / 2 h / Heating View Scheme
参考文献
Radl, Stanislav; Cerny, Josef; Stach, Jan; Gablikova, Zuzana
Organic Process Research and Development, 2013 , vol. 17, # 1 p. 77 - 86
反应条件
in xylene 1.5 h; Reflux;
参考文献
ZENTIVA, K.S.; RADL, Stanislav
Patent: WO2012/139536 A1, 2012 ;
Location in patent: Page/Page column 9 ;
反应条件
1: pyridine / dimethylformamide / 0.5 h / 0 °C 2: xylene / 2 h / Heating View Scheme
参考文献
Radl, Stanislav; Cerny, Josef; Stach, Jan; Holec, Jan; Pisa, Ondrej; Gablikova, Zuzana
Journal of Heterocyclic Chemistry, 2013 , vol. 50, # 4 p. 929 - 936
反应条件
1,8-diazabicyclo[5.4.0]undec-7-ene in dimethyl sulfoxide T=20°C; 3 h; Product distribution / selectivity;
参考文献
ZENTIVA, K.S.; RADL, Stanislav
Patent: WO2012/139536 A1, 2012 ;
Location in patent: Page/Page column 11-12 ;
反应条件
potassium carbonate in dimethyl sulfoxide T=20°C; 2 h; Product distribution / selectivity;
参考文献
ZENTIVA, K.S.; RADL, Stanislav
Patent: WO2012/139536 A1, 2012 ;
Location in patent: Page/Page column 16-17 ;
反应条件
1: pyridine / N,N-dimethyl-formamide / 0.5 h / 0 °C / Cooling with water-ice 2: xylene / 2 h / Reflux View Scheme
参考文献
ZENTIVA, K.S.; RADL, Stanislav
Patent: WO2012/139536 A1, 2012 ;
反应条件
1: potassium tert-butylate / 1-methyl-pyrrolidin-2-one / 4 h / 20 °C 2: pyridine / N,N-dimethyl-formamide / 0.5 h / 0 °C / Cooling with water-ice 3: xylene / 2 h / Reflux View Scheme
参考文献
ZENTIVA, K.S.; RADL, Stanislav; STACH, Jan
Patent: WO2012/139535 A1, 2012 ;
反应条件
1: hydroxylamine hydrochloride / dimethyl sulfoxide; water / 15 h / 90 °C 2: dimethyl sulfoxide; methanol / 2 h / 20 - 25 °C View Scheme
参考文献
Radl, Stanislav; Cerny, Josef; Stach, Jan; Gablikova, Zuzana
Organic Process Research and Development, 2013 , vol. 17, # 1 p. 77 - 86
反应条件
in methanol; dimethyl sulfoxide T=20 - 25°C; 2 h;
参考文献
Radl, Stanislav; Cerny, Josef; Stach, Jan; Gablikova, Zuzana
Organic Process Research and Development, 2013 , vol. 17, # 1 p. 77 - 86
反应条件
1.1: sodium hydroxide; water / 0.5 h / 50 - 55 °C 1.2: 0.5 h / 20 - 25 °C / pH 2 - 3 2.1: 4-(N,N-dimethlyamino)pyridine; potassium carbonate; p-toluoylsulfonylchloride / isobutyramide / -15 - 25 °C 2.2: 0.5 h / pH 4 - 5 View Scheme
参考文献
Radl, Stanislav; Cerny, Josef; Stach, Jan; Gablikova, Zuzana
Organic Process Research and Development, 2013 , vol. 17, # 1 p. 77 - 86