4-氧代-3-AZA-三环[4.2.1.0(2.5)]壬烷-7-烯合成路线 （共 7 条）
反应条件
sodium carbonate in dichloromethane T=0 - 20°C;
参考文献
Anadys Pharmaceuticals, Inc.
Patent: US2009/306057 A1, 2009 ;
Location in patent: Page/Page column 78-79 ;
反应条件
sodium hydrogencarbonate; sodium carbonate; sodium sulfite in dichloromethane; water T=5 - 20°C; pH=7 - 10; 1.25 h; Large scale reaction;
参考文献
Allwein, Shawn P.; Roemmele, Renee C.; Haley, James J.; Mowrey, Dale R.; Petrillo, Daniel E.; Reif, James J.; Gingrich, Diane E.; Bakale, Roger P.
Organic Process Research and Development, 2012 , vol. 16, # 1 p. 148 - 155
反应条件
1.1: dichloromethane / -15 - 15 °C / Large scale reaction 1.2: Large scale reaction 2.1: sodium hydrogencarbonate; sodium carbonate; sodium sulfite / dichloromethane; water / 1.25 h / 5 - 20 °C / pH 7 - 10 / Large scale reaction View Scheme
参考文献
Allwein, Shawn P.; Roemmele, Renee C.; Haley, James J.; Mowrey, Dale R.; Petrillo, Daniel E.; Reif, James J.; Gingrich, Diane E.; Bakale, Roger P.
Organic Process Research and Development, 2012 , vol. 16, # 1 p. 148 - 155
反应条件
hydrogenchloride in ethanol; chlorobenzene 12 h; Heating;
参考文献
Stajer, Geza; Szabo, Angela E.; Bernath, Gabor; Sohar, Pal
Synthesis, 1987 , # 3 p. 290 - 292
反应条件
hydrogenchloride in ethanol; chlorobenzene 11 h; Heating;
参考文献
Stajer, Geza; Szabo, Angela E.; Bernath, Gabor; Sohar, Pal
Synthesis, 1987 , # 3 p. 290 - 292
反应条件
hydrogenchloride in ethanol; chlorobenzene 13 h; Heating;
参考文献
Stajer, Geza; Szabo, Angela E.; Bernath, Gabor; Sohar, Pal
Synthesis, 1987 , # 3 p. 290 - 292
反应条件
hydrogenchloride Yield given;
参考文献
Stajer, Geza; Mod, Laszlo; Szabo, Angela E.; Fueloep, Ferenc; Bernath, Gabor; Sohar, Pal
Tetrahedron, 1984 , vol. 40, # 12 p. 2385 - 2393
