4-(4-氟苯基)-6-异丙基-2-[(N-甲基-N-甲磺酰)氨基]嘧啶-5-甲醇合成路线 （共 30 条）
反应条件
1.1: tetrabutylammomium bromide; hydrogen bromide / toluene; water / 1.5 h / 90 - 95 °C 2.1: sodium hydroxide / water; acetone 3.1: tetrabutylammomium bromide; dihydrogen peroxide / dichloromethane; water / 10 - 20 °C 3.2: 0.5 h / 20 °C 4.1: dichloromethane; water / 2 h / 20 °C 4.2: 0.5 h / Reflux 5.1: sodium t-butanolate / tetrahydrofuran / -20 - -15 °C View Scheme
反应条件
phosphorus tribromide in toluene; acetonitrile T=10 - 20°C; 1 h; Inert atmosphere;
参考文献
Kaneka Corporation
Patent: EP2351762 A1, 2011 ;
Location in patent: Page/Page column 9 ;
反应条件
sodium iodide; sodium hydrogensulfite in trans-decahydronaphthalene; ethyl acetate; mineral oil
反应条件
tetrabutyl-ammonium chloride in water; toluene
反应条件
tetrabutylammomium bromide in water; toluene
反应条件
1: 71.2 percent / 4-methylmorpholine-N-oxide, tetrapropyl-ammonium perruthenate, molecular sieves 4 Angstroem / CH2Cl2 / 2 h 2: 71.3 percent / acetonitrile / 14 h / Heating 3: 13 g / HF / acetonitrile / 1.5 h / Ambient temperature 4: 1.) Et2BOMe, 2.) NaBH4 / 1.) THF, MeOH, -78 deg C, 30 min, 2.) THF, MeOH, 3 h View Scheme
参考文献
Watanabe, Masamichi; Koike, Haruo; Ishiba, Teruyuki; Okada, Tetsuo; Seo, Shujiro; Hirai, Kentaro
Bioorganic and Medicinal Chemistry, 1997 , vol. 5, # 2 p. 437 - 444
反应条件
1: 71.2 percent / 4-methylmorpholine-N-oxide, tetrapropyl-ammonium perruthenate, molecular sieves 4 Angstroem / CH2Cl2 / 2 h 2: 71.3 percent / acetonitrile / 14 h / Heating 3: 13 g / HF / acetonitrile / 1.5 h / Ambient temperature View Scheme
参考文献
Watanabe, Masamichi; Koike, Haruo; Ishiba, Teruyuki; Okada, Tetsuo; Seo, Shujiro; Hirai, Kentaro
Bioorganic and Medicinal Chemistry, 1997 , vol. 5, # 2 p. 437 - 444
反应条件
2,2,6,6-tetramethyl-piperidine-N-oxyl; oxygen; dmgH2; cobalt(II) nitrate hexahydrate in dichloromethane T=70°C; P=3000.3 Torr; 3 h; Autoclave;
参考文献
Heterocyclic Communications, , vol. 20, # 1 p. 11 - 13
反应条件
1: 71.2 percent / 4-methylmorpholine-N-oxide, tetrapropyl-ammonium perruthenate, molecular sieves 4 Angstroem / CH2Cl2 / 2 h 2: 71.3 percent / acetonitrile / 14 h / Heating View Scheme
参考文献
Watanabe, Masamichi; Koike, Haruo; Ishiba, Teruyuki; Okada, Tetsuo; Seo, Shujiro; Hirai, Kentaro
Bioorganic and Medicinal Chemistry, 1997 , vol. 5, # 2 p. 437 - 444
反应条件
1: phosphorus tribromide / toluene; acetonitrile / 1 h / 10 - 20 °C / Inert atmosphere
2: toluene / 18 h / 20 °C / Inert atmosphere; Reflux
View Scheme
参考文献
Kaneka Corporation
Patent: EP2351762 A1, 2011 ;
