4-(4-氟苯基)-6-异丙基-2-[(N-甲基-N-甲磺酰)氨基]嘧啶-5-甲醇合成路线 （共 30 条）
反应条件
1: With diisobutylaluminium hydride in toluene T=-78 - 0°C; Inert atmosphere; 2: With water in toluene
参考文献
YUHAN CORPORATION; JU, Hyun; JOUNG, Sang-Sun; YI, Hyun-Jik; KHOO, Ja-Heouk; LIM, Jong-Chul; KIM, Jae-Gyu
Patent: WO2012/2741 A2, 2012 ;
Location in patent: Page/Page column 18 ;
WO 2012/002741 A2
反应条件
lithium borohydride; boron trifluoride diethyl etherate in tetrahydrofuran T=-5 - 20°C; 4 h; Reagent/catalystTemperature;
参考文献
Porton Fine Chemicals Ltd; LIN, Wenqing; ZHENG, Hongjie; YANG, Peng
Patent: EP2602250 A1, 2013 ;
Location in patent: Paragraph 0028; 0029 ;
反应条件
water in tetrahydrofuran 6 h; Reflux;
参考文献
Sterk, Damjan; Casar, Zdenko; Jukic, Marko; Kosmrlj, Janez
Tetrahedron, 2012 , vol. 68, # 9 p. 2155 - 2160
反应条件
1: With diisobutylaluminium hydride in hexane; toluene T=-10°C; 1 h; 2: With hydrogenchloride in methanol; hexane; water; toluene T=-10 - 40°C; 0.333333 h;
参考文献
CIBA SPECIALTY CHEMICALS HOLDING INC.
Patent: WO2004/103977 A2, 2004 ;
Location in patent: Page 23 ;
反应条件
1: N-bromosuccinmide / acetonitrile / 0.5 h / UV-irradiation; Inert atmosphere; Sealed flow reactor 2: sodium hydrogencarbonate; water / acetonitrile / 4 h / Reflux View Scheme
反应条件
methanol; sodium tetrahydroborate in tetrahydrofuran T=5 - 10°C;
参考文献
WO2010/23678 A1, ;
Page/Page column 15 ;
反应条件
sodium hydrogencarbonate; dimethyl sulfoxide; sodium iodide T=20°C; Kornblum oxidation; 71 h; Inert atmosphere;
参考文献
Tetrahedron, , vol. 68, # 9 p. 2155 - 2160
反应条件
1: potassium carbonate / acetone / 24 h / 20 °C 2: caesium carbonate / 2-methyl tetrahydrofuran / 10 h / 40 °C 3: triethylamine / dichloromethane / 8 h / -5 °C / Inert atmosphere 4: N-bromosuccinmide / acetonitrile / 0.5 h / UV-irradiation; Inert atmosphere; Sealed flow reactor 5: sodium hydrogencarbonate; water / acetonitrile / 4 h / Reflux View Scheme
反应条件
1: caesium carbonate / 2-methyl tetrahydrofuran / 10 h / 40 °C 2: triethylamine / dichloromethane / 8 h / -5 °C / Inert atmosphere 3: N-bromosuccinmide / acetonitrile / 0.5 h / UV-irradiation; Inert atmosphere; Sealed flow reactor 4: sodium hydrogencarbonate; water / acetonitrile / 4 h / Reflux View Scheme
反应条件
1: triethylamine / dichloromethane / 8 h / -5 °C / Inert atmosphere 2: N-bromosuccinmide / acetonitrile / 0.5 h / UV-irradiation; Inert atmosphere; Sealed flow reactor 3: sodium hydrogencarbonate; water / acetonitrile / 4 h / Reflux View Scheme
