3,5-双(三氟甲基)吡唑合成路线 （共 2 条）
反应条件
1: With hydrazine hydrate in ethanol 8 h; Cooling with iceReflux; 2: With sulfuric acid T=0°C; 0.25 h;
参考文献
Maspero, Angelo; Giovenzana, Giovanni B.; Monticelli, Damiano; Tagliapietra, Silvia; Palmisano, Giovanni; Penoni, Andrea
Journal of Fluorine Chemistry, 2012 , vol. 139, p. 53 - 57
反应条件
1.1: toluene-4-sulfonic acid / dichloromethane / 5 h / Reflux; Inert atmosphere 2.1: n-butyllithium / tetrahydrofuran / 0.25 h / -80 °C / Inert atmosphere 2.2: 2 h / -80 - 20 °C / Inert atmosphere 3.1: hydrogenchloride / methanol / 2 h / Inert atmosphere; Reflux 4.1: sulfur(IV) fluoride; hydrogen fluoride / 5 h / 100 °C / Autoclave View Scheme
参考文献
Gerus, Igor I.; Mironetz, Roman X.; Kondratov, Ivan S.; Bezdudny, Andrei V.; Dmytriv, Yurii V.; Shishkin, Oleg V.; Starova, Viktoriia S.; Zaporozhets, Olga A.; Tolmachev, Andrey A.; Mykhailiuk, Pavel K.
Journal of Organic Chemistry, 2012 , vol. 77, # 1 p. 47 - 56
