1: 1.) (CH3)2CuLi, 2.) HMPA / 1.) Et2O, -78 deg C, 5 h, 2.) Et2O, a) -78 deg C, 0.5 h, b) RT, 14 h 2: 85.2 percent / NaOH / methanol / 1.5 h / Heating View Scheme

N,N,N',N',N'',N''-hexamethylphosphoric triamide; dimethylcopper lithium 1.) Et2O, -78 deg C, 5 h, 2.) Et2O, a) -78 deg C, 0.5 h, b) RT, 14 h; Yield given. Multistep reaction;

1: 1.) (CH3)2CuLi, 2.) HMPA / 1.) Et2O, -78 deg C, 5 h, 2.) Et2O, a) -78 deg C, 0.5 h, b) RT, 14 h 2: 85.2 percent / NaOH / methanol / 1.5 h / Heating 3: SOCl2 / 0.33 h / 50 °C View Scheme