3-(Boc-氨基)-3-苯基丙酸合成路线 （共 12 条）
反应条件
sodium hydroxide in 1,4-dioxane; water T=20°C; 18 h;
参考文献
WO2011/42145 A1, ;
Page/Page column 53-54 ;
WO 2011/042145 A1
反应条件
sodium hydroxide in 1,4-dioxane; water
反应条件
1.1: diethyl ether / 6 h / 20 °C 2.1: O3 / CH2Cl2; methanol / 1 h / -78 °C 2.2: Me2S / CH2Cl2; methanol / 1 h / -78 - 20 °C 3.1: aq. NaClO2; NaH2PO4; 2-methyl-2-butene / 2-methyl-propan-2-ol / 1 h / 20 °C View Scheme
参考文献
Chemistry - A European Journal, , vol. 11, # 15 p. 4387 - 4395
反应条件
1: LiAlH4 / tetrahydrofuran 2: 72 percent / NaIO4; RuCl3 View Scheme
参考文献
Journal of the American Chemical Society, , vol. 127, # 15 p. 5376 - 5383
反应条件
sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene in tert-butyl alcohol T=20°C; 1 h;
参考文献
Chemistry - A European Journal, , vol. 11, # 15 p. 4387 - 4395
反应条件
1.1: EtMgBr / CH2Cl2; propan-2-ol; diethyl ether / 0 °C 1.2: 85 percent / propan-2-ol; CH2Cl2; diethyl ether / 0 - 20 °C 2.1: LiAlH4 / tetrahydrofuran / 0 - 20 °C 3.1: aq. K2CO3 / tetrahydrofuran / 20 °C / pH 10 4.1: 72 percent / aq. NaIO4; RuCl3 / CCl4; acetonitrile / 20 °C View Scheme
参考文献
Journal of the American Chemical Society, , vol. 125, # 23 p. 6846 - 6847
反应条件
1.1: diethyl ether / 6 h / 20 °C 2.1: O3 / CH2Cl2; methanol / 1 h / -78 °C 2.2: Me2S / CH2Cl2; methanol / 1 h / -78 - 20 °C 3.1: aq. NaClO2; NaH2PO4; 2-methyl-2-butene / 2-methyl-propan-2-ol / 1 h / 20 °C View Scheme
参考文献
Chemistry - A European Journal, , vol. 11, # 15 p. 4387 - 4395
反应条件
1.1: O3 / CH2Cl2; methanol / 1 h / -78 °C 1.2: Me2S / CH2Cl2; methanol / 1 h / -78 - 20 °C 2.1: aq. NaClO2; NaH2PO4; 2-methyl-2-butene / 2-methyl-propan-2-ol / 1 h / 20 °C View Scheme
参考文献
Chemistry - A European Journal, , vol. 11, # 15 p. 4387 - 4395
反应条件
potassium carbonate in methanol; water
参考文献
Bioorganic and Medicinal Chemistry, , vol. 6, # 10 p. 1707 - 1730
反应条件
sodium carbonate in tert-butyl alcohol
参考文献
The Journal of antibiotics, , vol. 19, # 6 p. 243 - 249
