ethanol; mercury dichloride und Erhitzen des Reaktionsprodukts mit Tri-O-acetyl-α-D-ribofuranosylchlorid in Xylol und Behandeln des Reaktionsprodukts mit methanol.NH3;

1: KMnO4 / acetic acid; H2O / 2 h 2: 78.9 percent / 50percent NaH / tetrahydrofuran / 6 h / Heating; investigation of the reaction with carbon nucleophiles 3: 9 percent / 0.05N NaOH / ethanol / 0.5 h / 60 °C View Scheme

1: K2CO3 / dimethylformamide 2: KMnO4 / acetic acid; H2O / 2 h 3: 78.9 percent / 50percent NaH / tetrahydrofuran / 6 h / Heating; investigation of the reaction with carbon nucleophiles 4: 9 percent / 0.05N NaOH / ethanol / 0.5 h / 60 °C View Scheme

1.1: n-butyllithium / tetrahydrofuran / 2 h / Heating 1.2: 79 percent / aq. sodium carbonate / tetrahydrofuran / 3 h / Heating 2.1: 96 percent / Dowex 50W-X8 (H+) resin; aq. ammonium hydroxide / methanol 3.1: hydrobromic acid; acetic acid / CH2Cl2 / 1.25 h / 20 °C 3.2: 27 percent / acetonitrile / 40 h / Heating 4.1: 93 percent / ammonium hydroxide / methanol; H2O / 18 h / 20 °C View Scheme

recombinant purine nucleoside phosphorylase from Aeromonas hydrophila in glycerol T=20°C; pH=7.5; aq. phosphate bufferEnzymatic reaction; regioselective reaction;

1.1: 96 percent / Dowex 50W-X8 (H+) resin; aq. ammonium hydroxide / methanol 2.1: hydrobromic acid; acetic acid / CH2Cl2 / 1.25 h / 20 °C 2.2: 27 percent / acetonitrile / 40 h / Heating 3.1: 93 percent / ammonium hydroxide / methanol; H2O / 18 h / 20 °C View Scheme

1: 75 percent / Brown's nickel / ethanol / 4 h / Heating 2: 75 percent / 10 h / 0 - 5 °C / Irradiation; with Vycor Filter 3: 88 percent / phenyltrimethylammonium perbromide / methanol / 0.17 h 4: 50 percent / K2CO3 / acetone / 24 h / Ambient temperature 5: 57 percent / NaI / acetone / 4 h / Ambient temperature 6: 88 percent / NaBH4 / methanol / 0.25 h / Ambient temperature 7: 75 percent / satd. NH3/MeOH / 2 h / Ambient temperature View Scheme

1: 75 percent / 10 h / 0 - 5 °C / Irradiation; with Vycor Filter 2: 88 percent / phenyltrimethylammonium perbromide / methanol / 0.17 h 3: 50 percent / K2CO3 / acetone / 24 h / Ambient temperature 4: 57 percent / NaI / acetone / 4 h / Ambient temperature 5: 88 percent / NaBH4 / methanol / 0.25 h / Ambient temperature 6: 75 percent / satd. NH3/MeOH / 2 h / Ambient temperature View Scheme

1: 88 percent / NaBH4 / methanol / 0.25 h / Ambient temperature 2: 75 percent / satd. NH3/MeOH / 2 h / Ambient temperature View Scheme

1: 57 percent / NaI / acetone / 4 h / Ambient temperature 2: 88 percent / NaBH4 / methanol / 0.25 h / Ambient temperature 3: 75 percent / satd. NH3/MeOH / 2 h / Ambient temperature View Scheme