2,6-二甲氧基苯甲酸合成路线 （共 118 条）
反应条件
thionyl chloride in toluene
参考文献
Eli Lilly and Company
Patent: US4416683 A1, 1983 ;
参考文献
Norris; Ware
Journal of the American Chemical Society, 1939 , vol. 61, p. 1418
反应条件
silver carbonate; copper(ll) bromide; palladium dichloride in tetrahydrofuran T=110°C; 24 h;
参考文献
Peng, Xuefeng; Shao, Xiang-Feng; Liu, Zhong-Quan
Tetrahedron Letters, 2013 , vol. 54, # 24 p. 3079 - 3081
反应条件
4-methyl-morpholine; diphenylphosphoranyl azide; hydrogen; copper monoiodide; benzyl alcohol; palladium in methanol; 1,2-dichloro-ethane
参考文献
US6124341 A1, ;
US 6124341 A
反应条件
1.1: thionyl chloride / N,N-dimethyl-formamide; toluene / 20 °C / Inert atmosphere 2.1: dichloromethane / 2 h / -78 - 20 °C / Inert atmosphere 2.2: 0.5 h / -78 - 20 °C / Inert atmosphere 2.3: 1 h View Scheme
参考文献
Zervosen, Astrid; Bouillez, Andre; Herman, Alexandre; Amoroso, Ana; Joris, Bernard; Sauvage, Eric; Charlier, Paulette; Luxen, Andre
Bioorganic and Medicinal Chemistry, 2012 , vol. 20, # 12 p. 3915 - 3924
反应条件
palladium (II) trifluoroacetate; dimethyl sulfoxide; silver carbonate; 2,2,2-trimethylacetic acid in 1,4-dioxane T=80°C; 24 h; Inert atmosphere;
参考文献
Zhang, Min; Zhou, Jun; Kan, Jian; Wang, Min; Su, Weiping; Hong, Maochun
Chemical Communications, 2010 , vol. 46, # 30 p. 5455 - 5457
反应条件
copper(I) oxide; palladium diacetate; dimethyl sulfoxide; silver carbonate in toluene
T=110°C; 2 h; chemoselective reaction;
参考文献
Wang, Jiantao; Cui, Zili; Zhang, Yuexia; Li, Huajie; Wu, Long-Min; Liu, Zhongquan
Organic and Biomolecular Chemistry, 2011 , vol. 9, # 3 p. 663 - 666
反应条件
1: 60 percent / HBr, AcOH / CHCl3 / 20 h / Ambient temperature
2: 70 percent / ICl / acetic acid / 1.) reflux, 3 h, 2.) room temperature, 18 h
View Scheme
参考文献
Kung; Kasliwal; Pan; Mach; Guo
Journal of Medicinal Chemistry, 1988 , vol. 31, # 5 p. 1039 - 1043
反应条件
1: thionyl chloride / 1 h / 25 °C
2: 52 percent / stannic chloride / CH2Cl2 / 2 h / Heating
3: 85 percent / benzene, aluminium bromide / benzene / 5 h / Ambient temperature
4: 86 percent / triethylamine / ethyl acetate / 2 h / 25 °C
5: 74 percent / N-chlorosuccinimide / CHCl3 / 3 h / Heating
6: 95 percent / aq. conc. HCl / methanol / 2 h / Heating
View Scheme
参考文献
Cue Jr.; Dirlam; Czuba; Windisch
Journal of Heterocyclic Chemistry, 1981 , vol. 18, # 1 p. 191 - 192
反应条件
Pd(2+)*2C5F9O2(1-); trifluoroacetic acid; 6-mbipy in tetrahydrofuran; water
T=130°C; 0.5 h; Microwave irradiation;
参考文献
Axelsson, Linda; Veron, Jean-Baptiste; Saevmarker, Jonas; Lindh, Jonas; Odell, Luke R.; Larhed, Mats
Tetrahedron Letters, 2014 , vol. 55, # 15 p. 2376 - 2380
