2,6-二甲氧基苯甲酸合成路线 （共 118 条）
反应条件
bromine; sodium acetate in acetic acid
Ambient temperature;
参考文献
Florvall, Lennart; Oegren, Sven-Ove
Journal of Medicinal Chemistry, 1982 , vol. 25, # 11 p. 1280 - 1286
反应条件
1: 78 percent / SOCl2 / CHCl3 / 0.5 h / 50 °C
2: 17 percent / Br2, AcONa / acetic acid / Ambient temperature
View Scheme
参考文献
Florvall, Lennart; Oegren, Sven-Ove
Journal of Medicinal Chemistry, 1982 , vol. 25, # 11 p. 1280 - 1286
反应条件
1: thionyl chloride / Heating
2: pyridine / 1 h / Heating
3: NaOH / dimethylsulfoxide
4: sulfuric acid / acetic acid
View Scheme
参考文献
Vrielynck; Wallet; Merlin
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 2000 , vol. 56 A, # 12 p. 2439 - 2450
反应条件
triphenyl-arsane; silver carbonate; palladium dichloride in dimethyl sulfoxide
T=150°C; 6 h;
参考文献
Becht, Jean-Michel; Catala, Cedric; Le Drian, Claude; Wagner, Alain
Organic Letters, 2007 , vol. 9, # 9 p. 1781 - 1783
反应条件
1: 60 percent / SO2Cl2 / CHCl3 / 0.5 h / Heating
2: SOCl2 / 0.23 h / Heating
3: butan-2-one / 2 h / Ambient temperature
View Scheme
参考文献
Florvall, Lennart; Oegren, Sven-Ove
Journal of Medicinal Chemistry, 1982 , vol. 25, # 11 p. 1280 - 1286
反应条件
1: 78 percent / SOCl2 / CHCl3 / 0.5 h / 50 °C
2: 17 percent / Br2, AcONa / acetic acid / Ambient temperature
3: SOCl2 / 1 h / Heating
4: butan-2-one / 0.5 h
View Scheme
参考文献
Florvall, Lennart; Oegren, Sven-Ove
Journal of Medicinal Chemistry, 1982 , vol. 25, # 11 p. 1280 - 1286
反应条件
1: SOCl2 / toluene / 1 h / Heating
2: butan-2-one / Ambient temperature
View Scheme
参考文献
Florvall, Lennart; Oegren, Sven-Ove
Journal of Medicinal Chemistry, 1982 , vol. 25, # 11 p. 1280 - 1286
反应条件
1: 97 percent / bromine / acetic acid / 1.5 h
View Scheme
参考文献
Florvall, Lennart; Oegren, Sven-Ove
Journal of Medicinal Chemistry, 1982 , vol. 25, # 11 p. 1280 - 1286
反应条件
1: SOCl2, DMF / CHCl3 / 2 h / Heating
2: CHCl3 / 24 h / Ambient temperature
3: 1.) HCl gas, 2.) BBr3 / 1.) CHCl3, 15 min, 2.) CH2Cl2, room temperature, 1.5 h
View Scheme
参考文献
de Paulis; Kumar; Johansson; Raemsby; Florvall; Hall; Angeby-Moeller; Ogren
Journal of Medicinal Chemistry, 1985 , vol. 28, # 9 p. 1263 - 1269
反应条件
1: SOCl2, DMF / toluene / 1 h / 65 °C
2: 51 percent / CHCl3 / 0.5 h / 25 °C
3: 51 percent / 3N HCl, BBr3 / CH2Cl2 / 0.5 h / 20 °C
4: 76 percent / 3N HCl, BBr3 / CH2Cl2 / 0.5 h / 20 °C
View Scheme
参考文献
de Paulis; Kumar; Johansson; Raemsby; Florvall; Hall; Angeby-Moeller; Ogren
Journal of Medicinal Chemistry, 1985 , vol. 28, # 9 p. 1263 - 1269
