2,4-二氨基-alpha-(4-羧基苯基)-alpha-2-丙炔基-6-蝶啶丙酸合成路线 （共 4 条）
反应条件
1: 720 mg / aq. NaOH / 2-methoxy-ethanol / 24 h / 20 °C View Scheme
参考文献
ALLOS THERAPEUTICS, INC.
Patent: US2011/190305 A1, 2011 ;
反应条件
1: 720 mg / aq. NaOH / 2-methoxy-ethanol / 24 h / 20 °C View Scheme
参考文献
Vaidya, Chitra M.; Wright, Joel E.; Rosowsky, Andre
Journal of Medicinal Chemistry, 2002 , vol. 45, # 8 p. 1690 - 1696
反应条件
in dimethyl sulfoxide T=120°C; 0.5 h;
参考文献
Vaidya, Chitra M.; Wright, Joel E.; Rosowsky, Andre
Journal of Medicinal Chemistry, 2002 , vol. 45, # 8 p. 1690 - 1696
反应条件
N-ethyl-N,N-diisopropylamine in 1-methyl-pyrrolidin-2-one T=120°C; 0.5 h; Reagent/catalyst;
参考文献
PLUS CHEMICALS S.A.; TEVA PHARMACEUTICALS USA, INC.; TISENI, Paolo, Simone; GALLUZZO, Christian; CANAVESI, Augusto; BILJAN, Tomislav
Patent: WO2013/96800 A1, 2013 ;
Location in patent: Page/Page column 17; 18 ;
