5,6,7,8-四氢-1-喹啉合成路线 （共 8 条）
反应条件
dihydrogen peroxide in acetic acid T=70 - 80°C; Oxidation; 1 h;
参考文献
Jacobs, Christoph; Frotscher, Martin; Dannhardt, Gerd; Hartmann, Rolf W.
Journal of Medicinal Chemistry, 2000 , vol. 43, # 9 p. 1841 - 1851
反应条件
1: 31.1 g / Me2NCOCl / CH2Cl2 / 10 h / 20 °C 2: aq. hydrochloric acid / 2 h / Heating 3: 3.14 g / thionyl chloride / methanol / 6 h / Heating View Scheme
参考文献
Guay, Daniel; Gauthier; Dufresne; Jones; McAuliffe; McFarlane; Metters; Prasit; Rochette; Roy; Sawyer; Zamboni
Bioorganic and Medicinal Chemistry Letters, 1998 , vol. 8, # 5 p. 453 - 458
反应条件
sodium hydrogencarbonate
参考文献
Roussel Uclaf
Patent: US4816465 A1, 1989 ;
反应条件
triethylamine; trichlorophosphate in dichloromethane Chlorination; reduction; 0.25 h;
参考文献
Jacobs, Christoph; Frotscher, Martin; Dannhardt, Gerd; Hartmann, Rolf W.
Journal of Medicinal Chemistry, 2000 , vol. 43, # 9 p. 1841 - 1851
参考文献
Meiji Seika Kaisha, Ltd.
Patent: US6498251 B1, 2002 ;
反应条件
1: With trifluoroacetic anhydride in dichloromethane T=0 - 20°C; 16 h; 2: With lithium hydroxide in dichloromethane; water T=20°C; 16 h;
参考文献
Mazet, Clement; Roseblade, Stephen; Koehler, Valentin; Pfaltz, Andreas
Organic Letters, 2006 , vol. 8, # 9 p. 1879 - 1882
反应条件
sulfuric acid; nitric acid T=70°C; 2 h;
参考文献
Uchida; Morita; Chihiro; Kanbe; Yamasaki; Yabuuchi; Nakagawa
Chemical and Pharmaceutical Bulletin, 1989 , vol. 37, # 6 p. 1517 - 1523
反应条件
1: With N,N-dimethylcarbamoyl chloride in dichloromethane
T=20°C;
2: With sodium hydroxide in dichloromethane; water
0.166667 h;
参考文献
TAIGEN BIOTECHNOLOGY CO. LTD.
Patent: WO2008/95058 A1, 2008 ;
Location in patent: Page/Page column 18-19 ;
