N-Boc-4-氧代-3-吡咯烷甲酸乙酯合成路线 （共 8 条）
反应条件
1: N-tert-butyloxycarbonyl-glycine ethyl ester With sodium hydride in toluene T=20°C; 1 h; 2: ethyl acrylate in toluene T=0°C; 4.5 h;
参考文献
Simpson, Graham L.; Gordon, Andrew H.; Lindsay, David M.; Promsawan, Netnepa; Crump, Matthew P.; Mulholland, Keith; Hayter, Barry R.; Gallagher, Timothy
Journal of the American Chemical Society, 2006 , vol. 128, # 33 p. 10638 - 10639
反应条件
1: in tetrahydrofuran T=0°C; 2: With potassium tert-butylate in tetrahydrofuran T=0 - 25°C;
参考文献
US2010/29686 A1, ;
Page/Page column 20 ;
US 20100029686 A1
反应条件
1.1: triethylamine / methanol / 4 h / 20 °C 2.1: sodium hydride / toluene / 5 h / 4 °C 2.2: 72.6 g / toluene / 2 h / 20 °C View Scheme
参考文献
Tetrahedron Letters, , vol. 48, # 29 p. 5023 - 5026
反应条件
potassium tert-butylate in toluene T=0°C; 0.5 h;
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , # 12 p. 1313 - 1318
反应条件
sodium ethanolate in ethanol Dieckmann reaction; 3 h; Heating;
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 13, # 24 p. 4399 - 4403
反应条件
water in dimethyl sulfoxide T=120 - 130°C; Krapcho reaction; 4 h;
参考文献
Lee, Ji Hoon; Lee, Kyung Seok; Kang, Yong Koo; Yoo, Kyung Ho; Shin, Kye Jung; Kim, Dong Chan; Kong, Jae Yang; Lee, Yeonhee; Lee, Sook Ja; Kim, Dong Jin
Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 24 p. 4399 - 4403
反应条件
1: NaBH3CN; HCl / methanol 2: 91 percent / PPh3; diethyl azodicarboxylate / toluene / 12 h / 20 °C View Scheme
参考文献
Wang, Xifang; Espinosa, Juan F.; Gellman, Samuel H.
Journal of the American Chemical Society, 2000 , vol. 122, # 19 p. 4821 - 4822
反应条件
potassium carbonate in acetone
T=20°C; 5 h;
参考文献
Kim, Sung-Gon; Lee, Sang Ho; Park, Tae-Ho
Tetrahedron Letters, 2007 , vol. 48, # 29 p. 5023 - 5026
