N-(1,1-二甲基乙基)-5-(2-甲基丙基)-2-噻吩磺胺合成路线 （共 3 条）
反应条件
1: thiophene-2-sulfonic acid tert-butylamide With n-butyllithium in tetrahydrofuran T=-78 - -40°C; 2.5 h; 2: iso-butyl iodide in tetrahydrofuran T=20°C;
参考文献
VICORE PHARMA AB
Patent: WO2006/109058 A1, 2006 ;
Location in patent: Page/Page column 36 ;
WO 2006/109058 A1
反应条件
1: thiophene-2-sulfonic acid tert-butylamide With n-butyllithium in tetrahydrofuran T=-78 - -40°C; 2.5 h; 2: iso-butyl iodide in tetrahydrofuran T=20°C;
参考文献
VICORE PHARMA AB; McNEENEY, Stephen, Phillip
Patent: WO2004/85420 A1, 2004 ;
Location in patent: Page 40-41 ;
WO 2004/085420 A1
反应条件
1: thiophene-2-sulfonic acid tert-butylamide With n-butyllithium in tetrahydrofuran T=-78 - -40°C; 2.5 h; 2: iodo-2-methylpropane in tetrahydrofuran T=20°C;
参考文献
Vicore Pharma AB; Mcneeney, Stephen, Philip
Patent: WO2004/46141 A1, 2004 ;
Location in patent: Page 42 ;
WO 2004/046141 A1
