3-氨基-3-苯基-1-丙醇合成路线 （共 25 条）
反应条件
1: With sodium tetrahydroborate in tetrahydrofuran 2: With methanesulfonic acid in tetrahydrofuran T=30°C; 3: With sodium hydroxide in tetrahydrofuran; water pH=9 - 10; Product distribution / selectivity;
参考文献
SYMED LABS LIMITED; MOHAN RAO, Dodda; KRISHNA REDDY, Pingili; JITHENDER, Aadepu; VENUGOPAL, Bingi
Patent: WO2011/161690 A1, 2011 ;
Location in patent: Page/Page column 22 ;
反应条件
sodium tetrahydroborate; sulfuric acid in tetrahydrofuran T=20°C;
参考文献
Kellogg, Richard M.; Nieuwenhuijzen, Jose W.; Pouwer; Vries, Ton R.; Broxterman, Quirinus B.; Grimbergen, Reinier F.P.; Kaptein, Bernard; La Crois, Rene M.; De Wever, Ellen; Zwaagstra, Karen; Van Der Laan, Alexander C.
Synthesis, 2003 , # 10 p. 1626 - 1638
反应条件
ammonia in tetrahydrofuran; water T=65°C; 16 h;
参考文献
EP1634886 A2, ;
Page/Page column 66 ;
反应条件
1: 35 percent / conc. H2SO4 / dibutyl ether / 17 h / Ambient temperature 2: 51 percent / 50percent aq. KOH / 24 h / Heating View Scheme
参考文献
Journal of Organic Chemistry USSR (English Translation), , p. 157 - 159
Zhurnal Organicheskoi Khimii, , vol. 18, # 1 p. 178 - 181
反应条件
1: ammonium acetate / ethanol / 6 h / Heating 2: LiAlH4 / tetrahydrofuran / 12 h / Heating View Scheme
参考文献
Tetrahedron Letters, , vol. 45, # 7 p. 1503 - 1505
反应条件
potassium hydroxide 24 h; Heating;
参考文献
Pavel', T. M.
Journal of Organic Chemistry USSR (English Translation), 1982 , p. 157 - 159
Zhurnal Organicheskoi Khimii, 1982 , vol. 18, # 1 p. 178 - 181
反应条件
1: With sulfuric acid; 2-hydroxy-2-methyl-propionitrile in hexane 2 h; Heating; 2: Alkaline hydrolysis;
参考文献
Chemistry of Heterocyclic Compounds, , vol. 37, # 5 p. 574 - 575
反应条件
1: 90 percent / Saccharomyces cerevisiae; glucose; phenacyl chloride / aq. phosphate buffer; diisopropyl ether / 48 h / 20 °C / pH 4.5 2: 65 percent / ammonium acetate; sodium cyanoborohydride / ethanol / 36 h / 20 °C View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 17, # 2 p. 240 - 244
反应条件
1: BH3*THF; (S)-4-isopropyl-5,5-diphenyl[1,3,2]oxazaborolidine / tetrahydrofuran / 0 - 20 °C 2: aq. NaOH; H2O2 / tetrahydrofuran / 1 h / Heating View Scheme
参考文献
Journal of the Chemical Society, Perkin Transactions 1, , # 20 p. 3362 - 3374
反应条件
1: (S)-4-isopropyl-5,5-diphenyl[1,3,2]oxazaborolidine; BH3*THF / tetrahydrofuran / 14 h / 20 °C 2: tetrahydrofuran / 1 h / 20 °C 3: aq. NaOH; H2O2 / tetrahydrofuran / 2 h / 20 °C View Scheme
参考文献
Journal of the Chemical Society, Perkin Transactions 1, , # 20 p. 3362 - 3374
