3-溴-5-(溴甲基)吡啶合成路线 （共 3 条）
反应条件
1: With phosphorus tribromide in dichloromethane T=0 - 20°C; 2 h; Inert atmosphere; 2: With triethylamine in dichloromethane 1 h; 3: With potassium carbonate in dichloromethane; water T=0°C; pH=7;
参考文献
THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING/MCGILL UNIVERSITY; TSANTRIZOS, Youla, S.; DE SCHUTTER, Joris, Wim; LIN, Yih-Shyan
Patent: WO2011/147038 A1, 2011 ;
Location in patent: Page/Page column 37 ;
反应条件
pyridine in tetrahydrofuran; dichloromethane
参考文献
American Home Products Corporation
Patent: US5250700 A1, 1993 ;
US 5250700 A
反应条件
1.1: chloroformic acid ethyl ester; triethylamine / tetrahydrofuran / 1 h / 0 - 20 °C / Inert atmosphere 1.2: 20 °C 2.1: phosphorus tribromide / dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere 2.2: 1 h 2.3: 0 °C / pH 7 View Scheme
参考文献
THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING/MCGILL UNIVERSITY; TSANTRIZOS, Youla, S.; DE SCHUTTER, Joris, Wim; LIN, Yih-Shyan
Patent: WO2011/147038 A1, 2011 ;
