4-甲基-2,1,3-苯并噻二唑合成路线 （共 11 条）
反应条件
hydrogenchloride; thionyl chloride in pyridine
参考文献
The Ohio State University
Patent: US6376664 B1, 2002 ;
反应条件
1: aq. HCl; SnCl2 2: 65 percent / thionyl chloride / benzene / 72 h View Scheme
参考文献
Journal of Organic Chemistry, , vol. 70, # 15 p. 6004 - 6017
反应条件
1: 71 percent / N-bromosuccinimide / CCl4 / 3 h / Heating; Irradiation 2: 68 percent / Li salt of 2-nitropropane / methanol / 24 h / Ambient temperature View Scheme
参考文献
Jonas, R; Pruecher, H; Wurziger, H
European Journal of Medicinal Chemistry, 1993 , vol. 28, # 2 p. 141 - 148
反应条件
hydrogen bromide; bromine T=126 - 130°C;
参考文献
Jorgensen, Mikkel; Krebs, Frederik C.
Journal of Organic Chemistry, 2005 , vol. 70, # 15 p. 6004 - 6017
反应条件
sulfuric acid; hydroxylamine; vanadium pentoxide T=100°C; 5 h;
参考文献
Sergeev,V.A.; Pesin,V.G.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1971 , vol. 7, p. 561 - 562
Khimiya Geterotsiklicheskikh Soedinenii, 1971 , vol. 7, # 5 p. 601 - 602
反应条件
magnesium in methanol T=45 - 60°C; 1.83333 h;
参考文献
Prashad, Mahavir; Liu, Yugang; Repic, Oljan
Tetrahedron Letters, 2001 , vol. 42, # 12 p. 2277 - 2279
反应条件
in sulfuric acid; water
参考文献
Salvati, Mark E.; Balog, James Aaron; Pickering, Dacia A.; Giese, Soren; Fura, Aberra; Li, Wenying; Patel, Ramesh N.; Hanson, Ronald L.; Mitt, Toomas; Roberge, Jacques Y.; Corte, James R.; Spergel, Steven H.; Rampulla, Richard A.; Misra, Raj N.; Xiao, Hai-Yun
Patent: US2004/77605 A1, 2004 ;
US 20040077605 A1
反应条件
1: 71 percent / N-bromosuccinimide / CCl4 / 3 h / Heating; Irradiation 2: 68 percent / Li salt of 2-nitropropane / methanol / 24 h / Ambient temperature 3: 67 percent / sodium borohydride / methanol / 24 h / Ambient temperature View Scheme
参考文献
Jonas, R; Pruecher, H; Wurziger, H
European Journal of Medicinal Chemistry, 1993 , vol. 28, # 2 p. 141 - 148
反应条件
N-bromosuccinmide in tetrachloromethane
参考文献
The Ohio State University
Patent: US6376664 B1, 2002 ;
反应条件
N-bromosuccinmide in tetrachloromethane 3 h; HeatingIrradiation;
参考文献
Heterocycles, , vol. 45, # 5 p. 955 - 962
