1-Boc-2-吡咯烷甲酸甲酯合成路线 （共 15 条）
反应条件
potassium carbonate in N,N-dimethyl-formamide T=20°C; 12 h;
参考文献
ASTRAZENECA AB; ASTRAZENECA UK LIMITED; BUTTERWORTH, Sam; FINLAY, Maurice, Raymond, Verschoyle; WARD, Richard, Andrew; KADAMBAR, Vasantha, Krishna; CHANDRASHEKAR, Reddy, C.; MURUGAN, Andiappan; REDFEARN, Heather, Marie
Patent: WO2013/14448 A1, 2013 ;
Location in patent: Page/Page column 103 ;
WO 2013/014448 A1
反应条件
1: pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester With potassium carbonate in N,N-dimethyl-formamide 0.833333 h; 2: methyl iodide in N,N-dimethyl-formamide 1 h;
参考文献
AstraZeneca AB; NPS PHARMACEUTICALS, INC.
Patent: US2007/259923 A1, 2007 ;
Location in patent: Page/Page column 8 ;
US 20070259923 A1
反应条件
triethylamine in acetonitrile 16 h;
参考文献
WO2007/122410 A1, ;
Page/Page column 103 ;
反应条件
triethylamine in dichloromethane T=0 - 20°C;
参考文献
WO2009/146112 A1, ;
Page/Page column 40 ;
WO 2009/146112 A1
反应条件
triethylsilane; palladium diacetate; triethylamine in ethanol 15 h; Ambient temperature;
参考文献
Sakaitani, Masahiro; Hori, Keiko; Ohfune, Yasufumi
Tetrahedron Letters, 1988 , vol. 29, # 24 p. 2983 - 2984
反应条件
1: N-Boc-pyrrolidine With sec.-butyllithium in tetrahydrofuran; hexane T=-30°C; 0.0833333 h; Inert atmosphere; 2: methyl chloroformate in tetrahydrofuran; hexane T=-30 - 20°C; Inert atmosphere;
参考文献
Organic Letters, , vol. 12, # 18 p. 4176 - 4179
反应条件
1: 50 percent / Candida antarctica lipase / aq. phosphate buffer / 25 h / 30 °C / pH 6.8 View Scheme
参考文献
Kurokawa, Masayuki; Shindo, Takeyuki; Suzuki, Masumi; Nakajima, Nobuyoshi; Ishihara, Kohji; Sugai, Takeshi
Tetrahedron Asymmetry, 2003 , vol. 14, # 10 p. 1323 - 1333
反应条件
1.1: dichloromethane / 4 h / 20 °C / Cooling with ice 2.1: potassium carbonate / acetonitrile / 0.25 h / 0 °C 2.2: 16 h / Reflux View Scheme
参考文献
ENDO PHARMACEUTICALS INC.; GUPTA, Sandeep; PRIESTLEY, Tony; LAPING, Nicholas, James
Patent: WO2014/28675 A1, 2014 ;
反应条件
1: 49 percent / Candida antarctica lipase / aq. phosphate buffer / 25 h / 30 °C / pH 6.8 2: 93 percent / NaBH4; LiCl View Scheme
参考文献
Kurokawa, Masayuki; Shindo, Takeyuki; Suzuki, Masumi; Nakajima, Nobuyoshi; Ishihara, Kohji; Sugai, Takeshi
Tetrahedron Asymmetry, 2003 , vol. 14, # 10 p. 1323 - 1333
反应条件
1: 50 percent / Candida antarctica lipase / aq. phosphate buffer / 25 h / 30 °C / pH 6.8 2: NaBH4; LiCl View Scheme
参考文献
Kurokawa, Masayuki; Shindo, Takeyuki; Suzuki, Masumi; Nakajima, Nobuyoshi; Ishihara, Kohji; Sugai, Takeshi
Tetrahedron Asymmetry, 2003 , vol. 14, # 10 p. 1323 - 1333
