1-(月桂酰氧基)-2,5-吡咯烷二酮合成路线 （共 8 条）
反应条件
N'-(3-dimethylaminopropyl)-N-ethylcarbodiimide in dichloromethane 3 h;
参考文献
Liu, Lei; Breslow, Ronald
Journal of the American Chemical Society, 2003 , vol. 125, # 40 p. 12110 - 12111
反应条件
1: in tetrahydrofuran T=0°C; Inert atmosphere; 2: With dicyclohexyl-carbodiimide in tetrahydrofuran T=20°C; Inert atmosphere;
参考文献
Santos, Jose L.; Oliveira, Hugo; Pandita, Deepti; Rodrigues, Joao; Pego, Ana P.; Granja, Pedro L.; Tomas, Helena
Journal of Controlled Release, 2010 , vol. 144, # 1 p. 55 - 64
反应条件
triethylamine in N,N-dimethyl-formamide T=20°C; 24 h;
参考文献
Burov; Yablokova; Dorosh; Shkarubskaya; Blank; Epstein; Fridkin
Russian Journal of Bioorganic Chemistry, 2006 , vol. 32, # 5 p. 413 - 419
反应条件
sodium hydrogencarbonate in ethylene glycol dimethyl ether; water T=20°C; 16 h;
参考文献
Vavrova, Katerina; Hrabalek, Alexandr; Dolezal, Pavel; Samalova, Lucie; Palat, Karel; Zbytovska, Jarmila; Holas, Tomas; Klimentova, Jana
Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 24 p. 5381 - 5390
参考文献
Dobashi, Akira; Ono, Tamami; Hara, Shoji; Yamaguchi, Junko
Analytical Chemistry, 1989 , vol. 61, # 17 p. 1984 - 1986
反应条件
sodium hydrogencarbonate in tetrahydrofuran; water
T=20°C; 16 h;
参考文献
Vavrova, Katerina; Hrabalek, Alexandr; Dolezal, Pavel; Samalova, Lucie; Palat, Karel; Zbytovska, Jarmila; Holas, Tomas; Klimentova, Jana
Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 24 p. 5381 - 5390
反应条件
1: 87 percent / tetrahydrofuran / 12 h / Ambient temperature
2: 55 percent / CrO3, 35percent H2SO4 / acetone / 3 h / Ambient temperature
View Scheme
参考文献
Korosec; Poljsak; Urleb
Archiv der Pharmazie, 1992 , vol. 325, # 4 p. 251 - 252
反应条件
in 1,4-dioxane
T=50 - 60°C; 4 h;
参考文献
Popovitz-Biro; Hill; Shavit; Hung; Lahav; Leiserowitz; Sagiv; Hsiung; Meredith; Vanherzeele
Journal of the American Chemical Society, 1990 , vol. 112, # 7 p. 2498 - 2506
