4,5,6,7-四氢苯并[b]噻吩-3-羧酸乙酯合成路线 （共 5 条）
反应条件
toluene-4-sulfonic acid; potassium iodide; sodium nitrite in water; acetonitrile T=20°C; 0.0833333 h;
参考文献
Nakhi, Ali; Adepu, Raju; Rambabu; Kishore, Ravada; Vanaja; Kalle, Arunasree M.; Pal, Manojit
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 13 p. 4418 - 4427
反应条件
1: With hydrogenchloride; sodium nitrite in 1,4-dioxane T=-5°C; 0.25 h; 2: With phosphoric acid in diethyl ether T=0°C; 0.5 h;
参考文献
Mitsumori, Susumu; Tsuri, Tatsuo; Honma, Tsunetoshi; Hiramatsu, Yoshiharu; Okada, Toshihiko; Hashizume, Hiroshi; Inagaki, Masanao; Arimura, Akinori; Yasui, Kiyoshi; Asanuma, Fujio; Kishino, Junji; Ohtani, Mitsuaki
Journal of Medicinal Chemistry, 2003 , vol. 46, # 12 p. 2446 - 2455
反应条件
1: morpholine; sulfur / ethanol / 90 °C 2: toluene-4-sulfonic acid; potassium iodide; sodium nitrite / water; acetonitrile / 0.08 h / 20 °C View Scheme
参考文献
Nakhi, Ali; Adepu, Raju; Rambabu; Kishore, Ravada; Vanaja; Kalle, Arunasree M.; Pal, Manojit
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 13 p. 4418 - 4427
反应条件
1: morpholine; sulfur / ethanol / 90 °C 2: toluene-4-sulfonic acid; potassium iodide; sodium nitrite / water; acetonitrile / 0.08 h / 20 °C View Scheme
参考文献
Nakhi, Ali; Adepu, Raju; Rambabu; Kishore, Ravada; Vanaja; Kalle, Arunasree M.; Pal, Manojit
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 13 p. 4418 - 4427
反应条件
sodium hydroxide in ethanol 0.5 h; Heating;
参考文献
Mitsumori, Susumu; Tsuri, Tatsuo; Honma, Tsunetoshi; Hiramatsu, Yoshiharu; Okada, Toshihiko; Hashizume, Hiroshi; Inagaki, Masanao; Arimura, Akinori; Yasui, Kiyoshi; Asanuma, Fujio; Kishino, Junji; Ohtani, Mitsuaki
Journal of Medicinal Chemistry, 2003 , vol. 46, # 12 p. 2446 - 2455
