3,5-二溴-1-甲基吡啶-2(1H)-酮合成路线 （共 14 条）
反应条件
1: 1H-3,5-dibromopyridine-2-one With potassium carbonate in N,N-dimethyl-formamide T=20°C; 0.25 h; 2: methyl iodide in N,N-dimethyl-formamide T=20°C; 18 h;
参考文献
CGI PHARMACEUTICALS, INC.
Patent: WO2008/33858 A2, 2008 ;
Location in patent: Page/Page column 127-128 ;
WO 2008/033858 A2
反应条件
1: 1H-3,5-dibromopyridine-2-one With potassium carbonate in N,N-dimethyl-formamide T=20°C; 0.25 h; 2: methyl iodide in N,N-dimethyl-formamide T=20°C; 18 h;
参考文献
CGI PHARMACEUTICALS, INC.
Patent: WO2008/33854 A1, 2008 ;
Location in patent: Page/Page column 63-64 ;
反应条件
bromine; acetic acid in dichloromethane T=20°C; 20 h;
参考文献
Messaoudi, Samir; Brion, Jean-Daniel; Alami, Mouad
Advanced Synthesis and Catalysis, 2010 , vol. 352, # 10 p. 1677 - 1687
反应条件
perchloric acid; bromine; potassium bromide in water 3 h; pH dependence; Rate constantMechanismProduct distribution;
参考文献
Tee, Oswald S.; Paventi, Martino
Journal of the American Chemical Society, 1982 , vol. 104, # 15 p. 4142 - 4146
反应条件
bromine; potassium bromide in water pH dependence; Rate constantMechanismProduct distribution;
参考文献
Journal of the American Chemical Society, , vol. 104, # 15 p. 4142 - 4146
反应条件
bromine; potassium bromide in water pH dependence; Rate constantMechanismProduct distribution;
参考文献
Journal of the American Chemical Society, , vol. 104, # 15 p. 4142 - 4146
反应条件
N-bromosuccinmide in N,N-dimethyl-formamide T=-10°C; 4 h; temperature 10 deg C; Product distribution;
参考文献
Chemistry of Heterocyclic Compounds (New York, NY, United States), , vol. 18, # 12 p. 1284 - 1286
Khimiya Geterotsiklicheskikh Soedinenii, , vol. 18, # 12 p. 1662 - 1664
反应条件
bromine; acetic acid
参考文献
Justus Liebigs Annalen der Chemie, , vol. 478, p. 22,35
反应条件
nachfolgende Oxydation mit Kaliumferricyanid in alkal. Loesung;
参考文献
Journal fuer Praktische Chemie (Leipzig), , vol. <2> 84, p. 447
反应条件
sodium azide; copper; 2-piperidinecarboxylic acid; ascorbic acid powder in ethanol T=100°C; Inert atmosphereSealed tube;
参考文献
Advanced Synthesis and Catalysis, , vol. 352, # 10 p. 1677 - 1687
